4－氨基吡啶诱发组胺释放及某些药物的拮抗作用  

4-AMINOPYRIDINE INDUCED HISTAMINE RELEASE AND ITS ANTAGONISM BY CERTAIN DRUGS

作　　者：徐建华[1] 吴昊妹 李莉[1] 

机构地区：[1]浙江医科大学药学系药理学教研室

出　　处：《药学学报》1994年第3期176-179,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：４－氨基吡啶（４－ＡＰ）有组胺释放作用。小鼠ｉｐ４－ＡＰ５ｍｇ·ｋｇ－１后，肺中组胺含量明显减低，血中组胺含量显著增高。钙拮抗剂硝苯啶、ＴＭＢ－８及钾通道开放剂米诺地尔均能明显抑制４－ＡＰ诱发的小鼠ＰＭＣ释放组胺。结果提示，ＭＣ可能存在钾通道，４－ＡＰ诱发ＭＣ释放组胺可能与它阻滞钾通道，从而使钙通道开放，增加Ｃａ２＋内流有关。Aminopyridine(4-AP),a known potassium channel blocker, was shown toinduce histamine release from mast cells in mice,After ip 4-AP 5 mg· kg-1 the histamine contentincreased in blood, but decreased in the lung tissue。Calcium antagonists nifedipine( NIF)500mg·kg-1ig,TMB-8 300 μmol·L-1 in vitro and potassium channel opener minoxidil(MIN)100mg· kg-1 inhibited the histamine release induced by 4-AP from mouse peritoneal mast cells(PMC)。These results provide evidence that potassium channels are present in mouse mast cell membranes andindicate that the mechanism of histamine release by 4-AP may be related to the potassium channelblocking effect.As the result of this effect ,the calcium channeis open and the Ca2+ influx to the mastcells increases, thus eliciting histamine release。

关 键 词：氨基吡啶 组胺释放 钙拮抗剂 

分 类 号：R965[医药卫生—药理学]