磁性微球的磁响应性及狗肾动脉栓塞实验研究  

STUDIES ON MAGNETIC RKSPONSIVENESS AND RENAL EMBOLIZATION WITH MAGNETIC MICROSPHERES IN DOGS

作　　者：吴传斌[1] 魏树礼[1] 卢炜[1] 赵延乐[1] 高文伟[1] 

机构地区：[1]北京医科大学药学院,北京中日友好医院,北京军事医学科学院毒物药物研究所

出　　处：《药学学报》1994年第4期311-315,共5页Acta Pharmaceutica Sinica

基　　金：国家医药管理局"八五"国家科技攻关专题

摘　　要：研究了磁性明胶微球（ＭＧ－ｍｓ）的磁响应性及狗肾动脉栓塞效果。磁响应性实验表明，介质流速越慢，磁场强度越大，磁性微球中磁铁粒子含量越高，越容易定位磁性微球。狗肾动脉灌注１０～３０ｕｍ磁性微球，血管造影和病理切片结果表明：磁性微球在外磁场作用下可以进一步栓塞至肾小球、肾脏的微细动脉，而且栓塞均匀、完全，而不加磁场时栓塞不完全。这些结果提示磁性明胶微球可以作为治疗肾癌的栓塞剂，将有利于增强化疗效果、减少毒副反应。The responsiveness and transcatheter embolization with magnetic gelatin micro-spheres(MG- ms)in dog kidney were reported.In experiments with magnet using a constant flowapparatus such as roller pump the percent retention was determined by counting the carrier retainedby the magnetic field and divided by the total starting counts,Factors influencing the percent retentionof MG-ms include :velocity of medium flow ,magnetic field intensity,α- Fe2O3 content in theMG-ms,viscositv of the medium and so on。Transcatheter embo1ization with MG-ms(10～ 30 um)was performed under external magnet control in dog kidney.The result of angiogram and histologica1section showed that the MG- ms were in the arteries ,arterioles , and glomerular capillaries with noadverse teactions.The embolized effect with magnet field was more prominent than the group withoutmagnet field.These results show that the MG-ms is a promising embolic agent for treatment of renalcancer under external magnet control。

关 键 词：磁性 明胶微球 肾动脉栓塞 

分 类 号：R944[医药卫生—药剂学]