人参皂甙Rb1和Rg1促智作用机制的探讨──对小鼠脑神经发育的影响  

STUDY ON THE NOOTROPIC MECHANISM OF GINSENOSDE Rb1 AND Rg1 INFLUENCE ON MOUSE BRAIN DEVELOPMENT

作　　者：杨迎[1] 张均田[1] 石成璋 屈志炜[1] 刘雨[1] 

机构地区：[1]北京卫生部食品卫生监督检验所,中国医学科学院,中国协和医科大学药物研究所

出　　处：《药学学报》1994年第4期241-245,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金

摘　　要：以０．１２５，０．２５ｍｇ·ｍｌ－１的人参皂甙Ｒｂ１和Ｒｇ１水溶液作为刚断乳小鼠唯一的饮用水，喂养４周至新成年。对照组动物给自来水，人参皂甙摄入量为Ｒｂ１２８．６及５６．１ｍｇ·ｋｇ１－１；Ｒｇ１２７．４及５３．９ｍｇ·ｋｇ－１。结果发现Ｒｂ１和Ｒｇ１均可促进幼鼠身体发育和脑神经发育，并易化小鼠成年后跳台法和避暗法记忆获得过程。用突触定量技术，首次发现较长期给予Ｒｂ１和Ｒｇ１可明显增加小鼠海马ＣＡ３区椎体细胞上层的突触数目（Ｐ＜０．０１），从而揭示了人参皂甙促进动物学习记忆的组织形态学基础。Weaning mice were supplied drinking water containing Rb1 or Rg1 0.125 or 0.25mg·ml-1 for 4 weeks.Rb1(28.6 and 56.1 mg·kg-1)and Rg1(27.4 and 53.9 mg·kg-1)were found to accelerate young mice body and brain development as well as facilitate memoryacquisition in step down and step through avoidance response tests. With the technique of quantitativemeasurement synapses ,we found for the first time that Rb1 and Rg1 administration for 4 weeks canincrease synapse number in the hippocampal CA3 region of mice. This is the morphological basis forexplaining Rb1 and Rg1 induced facilitation of learning and memory.

关 键 词：人参 皂甙 促智作用 脑神经发育 

分 类 号：R285.5[医药卫生—中药学]