喙柱牛奶菜抗生育成分的研究  

STUDIES ON THE ANTIFERTILITY CONSTITUENTS OF MARSDENIAOREOPHILA

作　　者：张玉娥[1] 阮金兰[1] 丁惟培[1] 

机构地区：[1]武汉同济医科大学计划生育研究所,中国医学科学院药物研究所

出　　处：《药学学报》1994年第4期281-284,共4页Acta Pharmaceutica Sinica

摘　　要：从喙柱牛奶菜Ｍａｒｓｄｅｎｉａｏｒｅｏｐｈｉｌａ甲醇提取物中获得一孕甾四糖甙，经化学反应，波谱分析，酸碱降解及水解确定其结构，命名为喙柱牛奶菜甙乙（ｍａｒｓｄｅｏｒｅｏｐｈｉｓｉｄｅＢ，ＩＩ），并证明为新化合物，动物实验初步证明该物有抗早孕活性。A new pregnane glycoside,marsdeoreophiside B was isolated from the stems ofMarsdenia oreophila(Asclepiadeaece).The structure was elucidated by means of chemical and spec-trometric analysis as 12-O-cinnamyldihydrosarcostin-3-O-β-D-glucopyranosyl(1→ 4)-O-3-O-methyl-6-deoxy-β-D-allopyranosyl(1→4)-O-β -D-oleandropyranosyl(1→4)-O-β-D-cymaropyranoside.Itshowed significant antifertility activity in rats.

关 键 词：喙柱牛奶菜 孕甾甙 抗早孕 

分 类 号：R282.710.5[医药卫生—中药学]