一种用于筛选降血糖及降血脂药物的动物模型  

AN ANIMAL MODEL FOR TESTING HYPOGLYEMIC AND HYPOLIPIDEMIC DRUGS

作　　者：刘京[1] 申竹芳[1] 刘海帆[1] 叶菲[1] 谢明智[1] 

机构地区：[1]中国医学科学院药物研究所,中国协和医科大学

出　　处：《药学学报》1994年第5期387-389,共3页Acta Pharmaceutica Sinica

摘　　要：一种用于筛选降血糖及降血脂药物的动物模型刘京，申竹芳，刘海帆，叶菲，谢明智（中国医学科学院药物研究所，中国协和医科大学北京１０００５０）糖尿病为常见病和多发病，同时伴有多方面的并发症，脂质代谢紊乱即其中之一。这就要求治疗糖尿病时，除控制病人的血糖外，...A new animal medel of hypergiycema and hyperlidemia was establislied bytreating normal Kunming mice with alloxan(iv);After different time intervals ,the levels of bloodglucose(BG)and serum triglyceride(TG)were determined.Forty-eight h after alloxanadministration ,the BG increased significantly,and the level of serum triglyceride reached maxium。The levels of blood glucose,serum triglyceride,cholesterol(CHOL )and free fatty acid(FFA )forvehicle treated mice were about 3.1,4.0,1.1,and 1. 7 times those of normal Kunming mice, respec-tively,To evaluate the new animal model, four drugs were use Two of them were antihyperglyce-mic drugs, metformin and a Recipe of Chinese Herbs(RC The other two were antihyperlipldemicagents ,clofibrate and fenofibrate。All drugs showed positlve effects on this kind of alloxan-diabeticKunming mice.It can be concluded that this kind of alloxan-treated Kunming mice is useful for testinghypoglycemic and hypolipidemic drugs。

关 键 词：降血糖药 降血脂药 动物模型 

分 类 号：R965.1[医药卫生—药理学]