甲基黄酮醇胺对豚鼠气管平滑肌收缩及cAMP水平的影响  

EFFECTS OF METHYLFLAVONOLAMINE HYDROCHLORIDE ON TENSION AND cAMP OF ISOLATED GUINEAPIG TRACHEA

作　　者：龙平[1] 阎超华[1] 张明升[1] 周尔凤[1] 

机构地区：[1]山西医学院药理教研室,山西省心血管疾病研究所

出　　处：《药学学报》1994年第5期321-325,共5页Acta Pharmaceutica Sinica

摘　　要：观察了ＭＦＡ对离体豚鼠气管张力，ｃＡＭＰ的影响及二者的关系。发现：ＭＰＡ（０．０３～０．６ｍｍｏｌ·Ｌ－１）剂量依赖性抑制ＫＣＩ，ＡＣｈ及Ｈｉｓｔ所致的气管条收缩，同时伴有ｃＡＭＰ升高，两者间有良好的相关性（ｒ值分别为０．７５３，０．９１１２和０．９５６７，Ｐ＜０．００１）；ＭＦＡ（０．０３ｍｍｏｌ·Ｌ－１）能够增强Ａｍｉ和Ｉｓｏ的气管平滑肌舒张作用，后者同时伴有ｃＡＭＰ升高。提示：ＭＦＡ对支气管平滑肌张力的抑制作用确与ｃＡＭＰ升高有关，ＭＦＡ升高ｃＡＭＰ作用可能与其钙拮抗作用有关。Effects of methylflavonolaminethy(4'-methyl-7-2-hydroxy-3-isopropy-laminopropoxy )-flavone hydrochloride,MFA)on the tension and cAMP content of isolated guinea pig tracheai smooth muscle strips were studied.MFA(0. 03～0. 6 mmol·L-1 )dose-dependently reduced KCl,acetylcholine(ACh )and histamine ( Hist)-induced contractions with intracellular increase in cvclic AMP.The reduction in contraction。and increase in cAMP were well correlated positively.MFA(0. 03 mmol·L-1)showed synergism with isoprenaline(Iso)and aminophylline(Ami)in bronchodi- lation.The synergism with Iso but not Ami was accompanied by an increase in cAMP Ievels. It is suggested that the MFA-induced bronchodilation is related to the increase in intracellular cAMP level。The calcium antagonistic effect may be involved in MFA-induced bronchodilation。

关 键 词：甲基黄酮醇胺 气管 环磷酸腺苷 

分 类 号：R965[医药卫生—药理学]