用光纤化学传感器连续在位监测甲硝唑片的体外溶出度  

CONTINUOUS IN SITU MONITORING OF THE DISSOLUTION RATE OF METRONIDAZOLE TABLETS USING A FIBER-OPTIC CHEMICAL SENSOR

作　　者：朱滨[1] 邢君芬[1] 陈坚[1] 

机构地区：[1]新疆医学院药学系,新疆临床药学研究所

出　　处：《药学学报》1994年第5期369-374,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金; 新疆自然科学基金

摘　　要：采用８０年代发展的新技术——光纤化学传感器连续在位监测了甲硝唑片的体外溶出过程，溶出曲线用三参量双指数函数拟合。方法的回收率为９９．７～１０２．３％，日内、日间精密度的相对标准偏差（ＲＳＤ）均小于３．０％。经与ＵＳＰ（ＸＸＩＩ）方法对照，各时间甲硝唑累积溶出量和拟合后提取的参数（除延迟时间Ｔｌａｇ）均无显著差异（ｐ＞０．０５）。甲硝唑片的主要溶出方式为未崩解片剂表面直接溶出．A new approach to the continuous monitoring in situ of the dissolution rate ofmetronidazole tablets using fiber-optic chemical sensor( FOCS )without fiItering and sampling isreported.It provided increasing amount of information on the dissolution test of tablets.The range ofrecovery(%)of the proposed method was 99.7￣102.3%,The precision(RSD)of within-day andday-to-day was less than 4%.The three parameter biexponential(TPBE)function was used to fit thedissolution curve,The results of measurement for the dissolution test of metronidazole tablets usingFOCS were in agreement with those of USP(XXII) method,and the FOCS methed was simple andaccurate。

关 键 词：化学传感器 甲硝唑 溶出度 

分 类 号：R927.11[医药卫生—药学]