动脉血压改变对大鼠下丘脑后部GABA释放的影响  

EFFECTS OF ARTERIAL BLOOD PRESSURE CHAN6E ON RELEASK OF GABA IN THE POSTERIOR HYPOTHALAMUS CONSCIOUS OF FREELY MOVING RATS

作　　者：郭莲军[1] 

机构地区：[1]同济医科大学基础医学院药理教研室

出　　处：《药学学报》1994年第6期401-405,共5页Acta Pharmaceutica Sinica

摘　　要：用推～挽灌流技术，定位灌流大鼠下丘脑后部，同时ｉｖ给予去氧肾上腺素（１５μｇ·ｋｇ·ｍｉｎ－１）和静脉输血（３ｍｌ／１００ｇ，ｗｔ）引起血压升高时，下丘脑后部γ－氨基丁酸（ＧＡＢＡ）的释放率增加，而ｉｖ给予硝普钠、氯化四氯吲哚铵和控制性失血导致血压下降时，ＧＡＢＡ的释放率减少。进一步证明下丘脑ＧＡＢＡ能神经系统参与外周动脉血压的调节，且有降压作用。Push-pull superfusion technique was used to investigate the release of endogenousgamma一aminobutyric acid(GABA)in the posterior hypothalamus of the conscious , freely moving ratin response to peripherally applied drugs or experimentally induced blood pressure changes. The rise in blood pressure elicited by intravenous infusion of phenylephrine(15μg·kg-1·min-1) or blood(3 ml/100g)was associated with an increased rate of GABA release in the posterior hypothalamus,Hypotension preduced by nitroprusside(30μg· kg-1· min-1) ,chlorisondamine(3mg·kg-1,iv)and controlled bleeding(3ml/100g)led to a counteracting decrease in hypothalamic GABA outflow.This finding suggests that GABAergic neurons of the conscious,freely moving rat in the posterior hypothalamus are involved in cardiovascular control and possess a hypotensive function.

关 键 词：下丘脑 Γ-氨基丁酸 运脉血压 

分 类 号：R338.27[医药卫生—人体生理学]