白细胞三烯拮抗剂ONO－1078对豚鼠迷走神经电刺激引起气道痉挛及微血管渗漏作用  

EFFECT OF A LEUKOTIENE ANTAGONIST,ONO-1078,ON ELEC-TRIC STIMULATION OF VAGUS(ESV)-INDUCED DRONCHO CONSTRICTION AND MICROVASCULAR LEAKAGE IN GUINEAPIGSEQ

作　　者：魏尔清[1] 王瑶尘[1] 陈丽萍[1] 唐法娣[1] 卞如濂[1] 

机构地区：[1]浙江医科大学药理学教研室

出　　处：《药学学报》1994年第7期487-491,共5页Acta Pharmaceutica Sinica

基　　金：浙江省自然科学基金

摘　　要：阿托品预先处理的豚鼠，电刺激迷走神经（１０Ｈｚ，５ｍｓ，２Ｖ或１０Ｖ，９０ｓ）引起气道阻力增高，气管、主支气管和肺内气道的依文思蓝渗出量增加，并随刺激强度加大而增强。白细胞三烯拮抗剂ＯＮＯ－１０７８（０．０３，０．１ｍｇ·ｋｇ－１，ｉｖ）对气道阻力的增高无明显影响；但显著抑制微血管渗漏，在刺激强度低（２Ｖ）时更明显。结果提示白细胞三烯类参与神经原性炎症时的气道微血管渗漏反应。In atropine-pretreated guinea pigs, electric stimulation of vagus(ESV,10 Hz,5ms,2V or 10V,for 90s)increased intrapulmonary pressure(IPP),and Evans blue extravasationin trachea,main bronchi,peripheral and distal intrapulmonary airways in a voltage-dependentmanner.ONO-1078,a noval leukotriene antagonist,(0.03 and0.1mg·kg-1,iv)showed noremarkable inhibiting effect on ESV-induced increase of IPP.However,the agent significantlyinhihited ESV-induced increase of Evans blue extravasation in the airways,especially in lower potencyof stimulation(2V).The results suggest that leukotrienes may be involved in airway microvascularleakage in response to neurogenic inflammation.

关 键 词：白细胞三烯 迷走神经 微血管 

分 类 号：R965[医药卫生—药理学]