藏、汉族健康人对安替比林及醋氨酚代谢的种族差异  

ETHNIC DIFFERENCES IN DISPOSITION OF ANTIPYRINE AND ACETAMINOPHEN BETWEEN TIBETAN AND HAN HEALTHY VOLUNTEERS

作　　者：贺平[1] 刘桂贤[1] 刘志红[1] 孙芳云[1] 李成义[1] 杨阳[1] 

机构地区：[1]西安第四军医大学唐都医院,西藏民族学院医学系

出　　处：《药学学报》1994年第8期566-569,共4页Acta Pharmaceutica Sinica

摘　　要：用随机交叉设计，研究了藏、汉族健康人安替比林和醋氨酚的代谢差异。１６例汉族人安替比林Ｔ１／２为１８．８±４．８９ｈ，１７例藏族人为１５．０±３．０２ｈ（Ｐ＜０．０５），汉族人安替比林清除率是１．３５±０．３７Ｌ·ｈ－１，藏族人是１．７１±０．４４Ｌｔ·ｈ－１（Ｐ＜０．０５）。汉族人醋氨酚Ｔ１／２是３．１±０．８６ｈ，藏族人是３．２±１．１２ｈ（Ｐ＞０．０５）。实验结果表明，藏、汉族健康人安替比林的代谢有显著差异，藏族人安替比林清除率比汉族人增加了２０％。藏、汉族醋氨酚的代谢无明显差异。The differences in disposition of antipyrine and acetaminophen between Tibetan and Han healthy volunteers were studied in a randomized crossover design. The half-life of antipyrine was found to be 18.8±4.89 h in 16 Han and 15.0±3.02 h in 17 Tibetan(P<0.05) and the clearance was 1.35±0.37 L·h-1 in Han and 1.71±0.44 L·h-1 in Tibetan(P<0.05). The half-life of acetaminophen was 3.1±0.86 h in Han and 3.2±1.12 h in Tibetan(P>0.05).The experimental results indicate that the disposition of antipyrine between Tibetan and Han healthy volunteers significantly differed,the clearance of antipyrine in Tibetan increased by 20%,but the disposition of acetaminophen between the two ethnic groups showed no difference.

关 键 词：安替比林 醋氨酚 药代动力学 

分 类 号：R969.1[医药卫生—药理学]