陵水暗罗活性成分研究  

STUDIES ON THE ACTIVE CONSTITUENTS OF POLY ALTHIA NEMORALISA.ETDC

作　　者：姚建忠[1] 梁华清[1] 廖时萱[1] 

机构地区：[1]上海第二军医大学药学院,上海第二军医大学基础部"五.二.三"药物研究室

出　　处：《药学学报》1994年第11期845-850,共6页Acta Pharmaceutica Sinica

摘　　要：从陵水暗罗（ｐｏｌｙａｌｔｈｉａｎｅｍｏｒａｌｉｓＡ．ｅｔＤＣ）根的乙醇提取物中分离得到五个化合物。经光谱（ＵＶ，ＩＲ，１Ｈ－ＮＭＲ，１３Ｃ－ＮＭＲ，ＤＥＰＴ和ＭＳ）解析和化学反应，分别鉴定为暗罗素（ｚｉｎｃｐｏｌｙａｎｅｍｉｎｅ，ＰＮ１），２－巯基吡啶－Ｎ－氧化物铜盐（ＰＮ２），β－谷甾醇（ＰＮ３），β－谷甾醇－β－Ｄ－吡喃葡萄糖甙（ＰＮ４）和２－巯基吡啶－Ｎ－氧化物－２－Ｓ－β－Ｄ－吡喃葡萄糖甙（ＰＮ５），其中ＰＮ５为新化合物，ＰＮ２为新天然产物。ＰＮ１和ＰＮ２有较强抗疟、防霉杀菌作用。ＰＮ５的抗疟、防霉试验尚在进行中。Five compouds have been isolated from the ethanol extracts of the roots of Polyal-thia nemoralis A.et DC..By means of spectrometric and physico-chemical analysis ,four of them wereidentified as zincpolyanemine(PN1),cupric bis(pyridine-N-oxide-2-thiolate)(PN2),β-sitosterol(PN3),andβ -sitosterol-3-O-β-D-glucopyranoside(PN4).PN2 is a new natural product. PN5 is a newcompound.Its structure was elucidated to be 2-thiohydroxy-pyridine-N-oxide-2- S-β -D-glucopyra-noside.Pharmacological tests showed that PN1 and PN2 possess strong antimalarial ,antimycotic andantiseptic activities.

关 键 词：陵水暗罗 防霉杀菌 巯基吡啶 吡喃葡萄糖甙 皂甙 

分 类 号：R284.1[医药卫生—中药学]