有机小分子与DNA的相互作用及其在DNA分析中的应用  

Interaction of small organic molecules with DNA and its analytical appl ication

作　　者：孙伟[1,2] 李清军[1] 焦奎[1] 陆路德[3] 

机构地区：[1]青岛科技大学化学与分子工程学院 [2]南京理工大学化工学院,江苏南京210094 [3]南京理工大学化工学院

出　　处：《化学试剂》2005年第3期149-152,共4页Chemical Reagents

基　　金：中国博士后科学基金 (2 0 0 3 0 3 3 492 ) ;国家自然科学基金 (2 0 3 75 0 2 0 ) ;青岛市自然科学基金 (0 4 2 JZ 114 )资助项目。

摘　　要：以有机小分子与DNA的作用机理为基础 ,从分光光度法、荧光法、光散射技术、电化学分析方法等多种分析手段出发 ,详细阐述了有机试剂在DNA分析中的最新应用进展 ,并对今后的发展趋势进行了展望。The interaction of DNA with small organic molecules c an be used not only to explain the mechanism of anti-tumor drugs and carcinogens but also to design the bio-probes for DNA analysis.In this paper the interactio n mode between small organic molecules and DNA was discussed carefully.The analy tical progresses of organic reagents in DNA determination were reviewed with dif ferent analytical techniques such as spectrophotometry,fluorometry,light-scatte ring technique and electrochemistry,42 papers were referred.

关 键 词：DNA 有机小分子 生物探针 相互作用 

分 类 号：O657.1[理学—分析化学]