试用本中心组方治疗1555例女性STD临床效果观察  

Comparison of two protocols for treatment of STD in 1555 female patients

作　　者：郑力争 张洪春 胡洪民 

机构地区：[1]河南省鹿邑县防疫站性病防治中心,鹿邑县477200

出　　处：《中国性科学》2005年第3期12-15,共4页Chinese Journal of Human Sexuality

摘　　要：目的:通过观察寻找出CDC指南推荐方案与本中心组方,在临床STD治疗中较为理想效果的合理组方并提示临床工作者注重女性STD治疗而杜绝因医治无效而引起的2代传播。方法:经筛选随机按1:1.3配对即CDC指南为观察组548例,中心组方为治疗组1007例临床观察且评定疗效。结果:观察组治愈率为78.65%。基本痊愈率15.7%;治疗组治愈率为94.44%,基本痊愈为4.28%。2者明显差异,副反应发生率治疗组大于观察组。胃肠道反应占总例数的12%-17%,神经系统症状占总例数的5%。结论:观察显示,治疗组中的2种或2种以上用药痊愈率高于观察组,但副反应发生率偏高(需对症处理)但不失为合理组方。Objective:To compare the efficacy of the protocol for treatment of STD recommended in CDC Guidebook, USA, and that composed by this center, and a more effective and rational protocol for treatment of STD in females, thereby eliminating mother- infant transmission due to ineffective therapy. Methods: 1555 female patients with STD were randomized into two groups in the proportion of 1 to 1.3: the CDC protocol group (n = 548) and our protocol group (n = 1007). Their efficacy was evaluated separately. Results: The cure rate and good response rate in the CDC protocol group were 78.65% and 15.7% , respectively, whereas those in our protocol group were 94.44% and 4.28% , respectively, with a significant difference. The occurrence rate of side effects in our protocol group was higher than that in the CDC protocol group; gastrointestinal reactions occurred in 12% - 17% of total number of patients and nervous system symptoms developed in 5% of total number of cases. Conclusions: The cure rate in our protocol group is higher than that in the CDC protocol group, but has a higher occurrence rate of side effects which need symptomatic treatment; it is a rattional protocol after all.

关 键 词：女性 STD 性传播疾病 阿奇霉素 阿昔洛韦 丽珠威 生殖器疱疹 

分 类 号：R711[医药卫生—妇产科学] R759[医药卫生—临床医学]