二聚体有机锡配合物{[n-Bu_2SnO_2CCH(CS_2NEt_2)_2]_2O}_2的合成、表征及晶体结构  

Synthesis, Characterization and Crystal Structure of Dimer Organotin Complex {[n-Bu_2SnO_2CCH(CS_2NEt_2)_2]_2O}_2

作　　者：尹汉东[1] 薛绳才[1] 王其宝[1] 

机构地区：[1]聊城大学化学化工学院,聊城252059

出　　处：《高等学校化学学报》2005年第4期631-633,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20271025);山东省自然科学基金(批准号:L2003B01)资助.

摘　　要：The title complex {[%n%|Bu-2SnO-2CCH(CS-2NEt-2)-2]-2O}-2 was synthesized and characterized by elemental analysis, IR, NMR and X|ray single crystal diffraction. The results show that the complex belongs to a monoclinic system with space group %C2/c%, and unit cell dimensions: %a%=2.848(5) nm, {%b%=1.381(2) nm}, %c%=3.239(6) nm, %β%=111.11(2)°, %Z=4, V%=11.884(35) nm+3, %D%-c=1.329 g/cm+3, {%F%(000)}=4 912, %S=0.991, R-1=0.053 5, wR-2=0.116 6.% The complex has a centrosymmetric dimer structure mode with a four|membered central %endo%|cyclic Sn-2O-2 unit. The %endo%|cyclic tin atoms are six|coordination and have coordition geometry of distorted octahedron. The %exo%|cyclic tin atoms are five|coordination and have coordination geometry of distorted trigonal bipyramid. This complex was tested %in vitro% against human tumour cell lines, MCF-7 and WiDr, and displayed the higher activity.The title complex {[%n%|Bu-2SnO-2CCH(CS-2NEt-2)-2]-2O}-2 was synthesized and characterized by elemental analysis, IR, NMR and X|ray single crystal diffraction. The results show that the complex belongs to a monoclinic system with space group %C2/c%, and unit cell dimensions: %a%=2.848(5) nm, {%b%=1.381(2) nm}, %c%=3.239(6) nm, %β%=111.11(2)°, %Z=4, V%=11.884(35) nm+3, %D%-c=1.329 g/cm+3, {%F%(000)}=4 912, %S=0.991, R-1=0.053 5, wR-2=0.116 6.% The complex has a centrosymmetric dimer structure mode with a four|membered central %endo%|cyclic Sn-2O-2 unit. The %endo%|cyclic tin atoms are six|coordination and have coordition geometry of distorted octahedron. The %exo%|cyclic tin atoms are five|coordination and have coordination geometry of distorted trigonal bipyramid. This complex was tested %in vitro% against human tumour cell lines, MCF-7 and WiDr, and displayed the higher activity.

关 键 词：有机锡配合物 双(N N-二乙基二硫代甲氨酰)乙酸 合成 晶体结构 生物活性 

分 类 号：O614.43[理学—无机化学] O643.11[理学—化学]