丹酰基丝氨酸与桥联双环糊精作用机理的时间分辨荧光光谱研究  

Time-resolved Fluorescence Spectroscopic Studies on Interaction Mechanism of Dansyl-L-serine with Bridged-bicyclodextrins

作　　者：陈凯[1] 贾树岩[1] 郝雅琼[1] 吴立新[1] 吴玉清[1] 刘俊秋[1] 刘瑞斌[2] 张建平[2] 艾希成[2] 

机构地区：[1]吉林大学超分子结构和材料教育部重点实验室,长春130012 [2]分子动态和稳态结构国家重点实验室,中国科学院化学研究所分子科学中心,北京100080

出　　处：《高等学校化学学报》2005年第4期693-696,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20373017;20473028和20003004);国家重点基础研究发展规划(批准号:G2000078102)资助.

摘　　要：利用稳态、时间分辨荧光光谱,结合非线性最小二乘法拟合系统研究了手性探针分子丹酰-L-丝氨酸(DLS)与β-环糊精(β-CD)、2-位硒桥联β-CD(1)和2-位碲桥联β-CD(2)的复合及复合机理.对比研究了DLS与三种不同环糊精复合强度及复合方式的差别.结果表明,引入硒桥键不能使化合物1与丹酰基丝氨酸分子很好地复合;而引入碲桥键使化合物2对DLS分子的结合能力相对于β-CD有明显增强.Time-resolved fluorescence spectra were applied to study the binding of dansyl-L-serine(DLS) with β-cyclodextrin(β-CD), 2-selenium bridged β-cyclodextrin(1) and 2-tellurium bridged β-cyclodextrin(2). The differentiations of DLS in binding with three kinds of cyclodextrins were performed. The results suggest that compound 1 cannot bind with DLS efficiently. However, compound 2 can enhance the binding ability with DLS greatly in comparison with that of β-CD.

关 键 词：丹酰基丝氨酸 硒桥联双环糊精 碲桥联双环糊精 非线性最小二乘法拟合 时间分辨荧光光谱 

分 类 号：O643[理学—物理化学] O657[理学—化学]