丹皮多糖一般药理学研究  

Study on the General Pharmacological Action of Polysaccharides from Mudan Cortex

作　　者：彭代银[1] 韩岚[1] 张丛芬[1] 沈业寿[2] 赵帜平[2] 

机构地区：[1]安徽中医学院药学院,安徽合肥230031 [2]安徽大学生命科学院

出　　处：《安徽中医学院学报》2005年第2期30-32,共3页Journal of Anhui Traditional Chinese Medical College

基　　金：安徽省"十五"重大科技专项(Z0640023)

摘　　要：目的: 观察丹皮多糖(PSM)主要药效学以外的药理作用, 为临床用药提供参考。方法:观察用药前后大鼠、小鼠自主活动行为能力,家猫呼吸频率、呼吸深度和狗血压、心率的变化情况。结果: 用药后大鼠、小鼠自主活动行为能力,家猫呼吸频率、呼吸深度及狗血压、心率均无明显变化。用药前后比较, 差异无显著性(P>0. 05)。结论: 在药效剂量下PSM对大鼠、小鼠的神经系统,家猫呼吸系统及狗的心血管系统系统均无明显影响。Objective: To observe the general pharmacological action of polysaccharides from mudan cortex(PSM) except main pharmacodynamics. Method: The blood pressure , heart beat rate , heart rhythm in dogs , respiratory rate and depth of respiration in cats and the times of freedom movement in mice and rats were studied before and after given PSM. Result: The blood pressure , heart beat rate , heart rhythm , respiratory rate and depth of respiration freedom movement in animals have no obvious difference after given PSM(P>0.05).Conclusion: PSM in effective dose have no obvious influence on nervous system in mice and rats, respiratory system(respiration rhythms, respiration depth)in cats and cardiovascular system in dogs.

关 键 词：丹皮多糖 一般药理学 

分 类 号：R965.3[医药卫生—药理学]