血管内皮生长因子在子宫内膜异位症发病中的作用  

Role of vascular endothelial growth factor in the pathogenesis of endometriosis

作　　者：金海燕[1] 王自能[1] 卢凤昕[1] 李明娥[2] 

机构地区：[1]暨南大学医学院妇产科,广东广州510632 [2]山西医科大学第一临床医学院妇产科,山西太原030001

出　　处：《基础医学与临床》2005年第3期257-260,共4页Basic and Clinical Medicine

摘　　要：目的探讨血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)在子宫内膜异位症(endometriosis,EM)发病中的作用。方法应用免疫组织化学方法并结合图像分析技术。结果正常子宫内膜和EM在位内膜腺上皮细胞的VEGF随月经周期呈现规律性变化,分泌期腺上皮VEGF蛋白表达量显著高于增殖期(P<0.05)。在增殖期,EM在位子宫内膜腺上皮VEGF的表达与正常子宫内膜相比无明显差别,但在分泌期,EM在位子宫内膜腺上皮细胞中VEGF的表达强度明显高于正常子宫内膜(P<0.01)。EM在位内膜腺上皮的VEGF含量显著高于同组卵巢子宫内膜异位囊肿的异位腺上皮(P<0.01)。结论表明VEGF的表达异常与EM的发病有关。Objective Immunohistochemical study and image analysis were used to study the role of vascular endothelial growth factor(VEGF) in the pathogenesis of endometriosis. Methods Revealed that immunostaining intensity of VEGF in eutopic endometrial epithelial cells of normal cycling women and patients with endometriosis was cycle-dependent. Results The content of VEGF was considerablely higher in the secretory phase compared with that in the proliferative phase(P<0.05). In the proliferative phase, the intensity of VEGF expression in eutopic endometrial epithelial cells of endometriosis showed no difference, when compared with that of normal endometrium. In the secretory phase, the expression of VEGF in eutopic endometrial epithelial cells of endometriosis was significantly higher, when compared with that of normal endometrium(P<0.01). Eutopic endometrium of endometriosis showed a higher VEGF expression than ectopic endometrium of ovarian endometriosis did(P<0.01). Conclusion Abnormal expression of VEGF might play a significant role in the pathogenesis of endometriosis.

关 键 词：血管内皮生长因子 子宫内膜异位症 发病 卵巢子宫内膜异位囊肿 正常子宫内膜 免疫组织化学方法 子宫内膜腺上皮 腺上皮细胞 factor 图像分析技术 VEGF蛋白 在位子宫内膜 在位内膜 方法应用 月经周期 表达异常 增殖期 分泌期 EM 规律性 表达量 

分 类 号：R711.71[医药卫生—妇产科学]