不同糖耐量者血清丙二醛及超氧化物歧化酶水平的变化  

Serum superoxide dismutase level and malondiadehyde level in subjects with different glucose tolerance.

作　　者：王丽宏[1] 艾静[2] 张巾超[1] 李强[1] 杨梅[2] 杨宝峰[2] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌科,150086 [2]哈尔滨医科大学药理教研室

出　　处：《中国实用内科杂志》2005年第4期311-312,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的分析不同糖耐量时氧化应激的变化及其与胰岛素抵抗(IR)的关系.方法2003-05～12哈尔滨医科大学附属第二医院测正常人、肥胖、糖耐量减低(IGT)和新诊断2型糖尿病(T2DM)患者血清丙二醛(MDA)及超氧化物歧化酶(SOD)水平,分析两指标与胰岛素敏感指数(ISI)的关系.结果肥胖组和IGT组已存在氧化应激.MDA与ISI呈显著负相关,SOD与ISI呈显著正相关(均P＜0.01).结论T2DM患者IR可能与氧化应激有关.Objective To investigate the state of oxidative s tr ess in patients with different glucose tolerance and the relationship between ox idative stress and insulin resistance(IR).Methods The levels of serum superoxide dismutase (SOD) and malo ndiadehyde(MDA)were measured in subjects of controls,obesity,impaired glucose to lerance (IGT) and newly diagnosed type 2 diabetes mellitus(T2DM).Results Oxidative stress has already existed in obesity and IGT group.MDA level was negatively correlated with insulin sensitive index (ISI) an d SOD level was positively correlated with ISI(all P<0.01).Conclusion Oxidative stress may play a role in the deveopment o f insulin resistance in T2DM.

关 键 词：糖耐量 氧化应激 血清丙二醛 IGT 肥胖 患者 诊断 ISI 水平 结论 

分 类 号：R587[医药卫生—内分泌] R541.4[医药卫生—内科学]