胰岛素治疗与胰岛B细胞休息的相关性研究  

Relationship among insulin treatment and pancreatic Bcell rest.

作　　者：于学满[1] 赵晓娟[1] 王璐[2] 

机构地区：[1]中国医科大学第一临床学院内分泌科,沈阳110001 [2]沈阳市第五人民医院,110023

出　　处：《中国实用内科杂志》2005年第4期313-314,共2页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨短期胰岛素强化治疗对2型糖尿病(T2DM)患者胰岛B细胞功能的影响.方法2003-11～2004-09在中国医科大学第一临床学院收治T2DM患者,应用化学免疫发光法测定强化治疗前后T2DM患者血清胰岛素和C肽水平.结果强化治疗后的T2DM患者OGTT试验中0、30、60、120、180min血清胰岛素和C肽水平均较治疗前明显升高.结论短期胰岛素强化治疗可使胰岛素分泌减低的T2DM患者胰岛B细胞得到休息,从而促其功能部分恢复.Objective To study the effect of short-term inte ns ive insulin treatment on the pancreatic B-cell function in type 2 diabetic mell itus (T2DM).Methods Insulin and C-peptide serum levels were measured befor e and after intensive insulin treatment in T2DM by chemical luminescence immunoa ssay.Results The levels of insulin and C-peptide were increased at 0、30、60、120、180min in OGTT in T2DM after insulin intensive treatment.Conclusion Short-term intensive insulin treatment can partiall y improve the B-cell function of T2DM with lower function and made it rest.

关 键 词：胰岛B细胞 患者 休息 T2DM 短期胰岛素强化治疗 胰岛素治疗 血清胰岛素 学院 水平 结论 

分 类 号：R587.1[医药卫生—内分泌] R532[医药卫生—内科学]