微球堆积法制备多孔磷酸钙生物材料  

Fabrication of Calcium Phosphate Porous Biomaterials Prepared by Close-packed with Microspheres

作　　者：王彦伟[1] 蔡舒[1] 彭珍珍[1] 姚康德[2] 

机构地区：[1]天津大学先进陶瓷与加工技术教育部重点实验室,天津大学材料学院 [2]天津大学高分子材料研究所,天津300072

出　　处：《材料科学与工程学报》2005年第2期235-238,共4页Journal of Materials Science and Engineering

基　　金：天津市重大基金资助项目 (0 0 380 50 1 1 )

摘　　要：以壳聚糖为原料 ,用乳液凝固法合成了壳聚糖微球。利用造孔剂成孔的特点 ,在有机模具中将壳聚糖微球紧密堆积 ,形成孔隙率至少为 2 6 %的多孔结构的框架 ,再将料浆灌注到框架中 ,充满空隙。干燥后经 6 0 0°C煅烧和12 0 0°C烧结 ,将有机模具及壳聚糖微球烧去 ,获得具有大孔和贯通式微孔的多孔磷酸钙生物材料。材料孔隙率在 6 0～70 %之间 ,大孔直径为 80 μm～ 2 5 0 μm ,孔径可控且分布均匀 ,平均抗压强度为 4 .5 8MPa。Chitosan microspheres were prepared by emulsion-solidification method, which were stacked in a polymer mould according to the closed-packed cubic structure to form a porous mesh like preformed body with a void volume of at least 26%. The preformed body was impregnated with ceramic slurry of a calcium phosphate-based compound, and then dried to obtain a green compact. The compact was calcined at 600 °C and sintered at 1200 °C to form porous calcium phosphate biomaterials. The porous bodies by this technique were found to have tractable and interconnected porosity in the range of 60～70%, with typical pore sizes ranging from 80～250μm, and the compressive strength was 4.58MPa.

关 键 词：磷酸钙 壳聚糖微球 框架 

分 类 号：TB39[一般工业技术—材料科学与工程]