HPLC法测定盐酸依托必利分散片的含量  

Determination of Itopride hydrochloride Dispersing Tablets by HPLC

作　　者：张冬梅 刘冰[2] 李琳琳 邢燕 

机构地区：[1]威海市药品检验所,威海264200 [2]威海职业技术学院,威海264200

出　　处：《齐鲁药事》2005年第3期147-148,共2页qilu pharmaceutical affairs

摘　　要：目的　建立HPLC测定盐酸依托必利含量的方法。方法　样品用水溶解,流动相为0 .0 5mol·L-1醋酸钠溶液(冰醋酸调pH =5 . 0) -甲醇(6 0∶4 0 ),色谱柱为C18柱,检测波长为2 5 8nm。结果　其线性回归方程Y =12 . 4 9+38 .15 4 0X,相关系数r =0 . 9998(n =6);加样回收率平均为99 .0 %。结论　方法操作简便,分析结果准确可靠。Objective To determine the content of Itopri de hydrochloride by HPLC.Methods The samples were dissolved in water.The mobile phase was composed of 0.05mol·L -1 sodium aceta te so lution(adjusted with glacial acetic acid to a pH of 5.0):methyl alcohol(60∶40 ) .The separation was performed on C 18 column.The detection wave length wa s 258nm.Results Its linear regression equation was Y=12 .49+38.1540X.The correlation coefficient was 0.9998(n=6).The averag e recovery of added samples was 99.0%.Conclusion The method is rapid,simple and accurate.

关 键 词：盐酸依托必利分散片 含量测定 高效液相色谱法 

分 类 号：TQ460.72[医药卫生—药物分析学]