前列地尔注射液对急性心肌梗死患者梗死面积及心功能的影响  

Influence of prostaglandin E_1 injection on infarct area and cardiac function in acute myocardial infarction patients

作　　者：朱稚丹[1] 周建华[1] 

机构地区：[1]广东省汕头市中心医院,广东汕头515031

出　　处：《现代中西医结合杂志》2005年第8期995-996,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的　观察前列地尔注射液对急性心肌梗死患者梗死面积及心功能的影响。方法　将 88例急性前壁心肌梗死患者随机分为治疗组 4 6例和对照组 4 2例 ,2组均予常规治疗 ,治疗组在此基础上加用前列地尔注射液。记录每例患者入院即刻和第 3,7,14 ,2 1天的 12导联心电图 ,用Wagner的QRS记分法进行QRS记分 ,预测梗死面积 ;在治疗 3周后行彩色多普勒超声心动图检查测定左室收缩功能。结果　治疗 2周后 ,治疗组QRS记分较对照组显著降低 ,左心室射血分数 (LVEF)明显增高。结论　前列地尔注射液对防止急性心肌梗死患者的梗死面积延展、缩小梗死面积。Objective It is to observe the effect of prostaglandin E1 (PGE 1) injection on the infarct area and cardiac function in acute myocardial infarction (AMI) patients. Methods 88 patients with anterior wall AMI were randomly divided into treatment group (46 cases) and control group (42 cases). Both the groups were treated with conventional therapy and the treatment group was given PGE1 injection additionally. The 12 leads electrocardiograms in all patients were recorded on admission, the 3rd day, the 7th day, the 14th day and the 21st day after hospitalization. The infarct area was estimated by ORS scoring method of Wagner. The left ventricular systolic function was measured by color Doppler echocardiography three weeks after treatment. Results The QRS scores were obviously less and the left ventricular ejection fractions (LVEF) were more in treatment group than in control group two weeks after treatment. Conclusion PGE 1 injection has some action on preventing the ductility of infarct area, deflating infarct area, protecting the ischemia myocardium and recovering the cardiac function in patients with AMI.

关 键 词：前列地尔注射液 梗死面积 患者 急性心肌梗死 心功能 治疗组 QRS记分 降低 防止 

分 类 号：R542.22[医药卫生—心血管疾病] R541[医药卫生—内科学]