胰岛素联用吡格列酮治疗磺脲类继发失效的2型糖尿病的研究  

Study of insulin combined with pioglitazone on type 2 diabetes with sulfonylurea secondum refractoriness

作　　者：蔺金华[1] 宋玉清[1] 吴永新[1] 

机构地区：[1]广东省梅州市人民医院,广东梅州514031

出　　处：《现代中西医结合杂志》2005年第8期999-1000,共2页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的　观察胰岛素或胰岛素加吡格列酮治疗磺脲类继发失效 2型糖尿病的疗效和安全性。方法　将 86例磺脲类继发失效的 2型糖尿病患者随机分为 2组 ,A组仅予胰岛素治疗 ,B组予胰岛素和吡格列酮治疗 ,疗程均为 8周。结果　 8周后 86例患者空腹血糖及餐后 2h血糖、糖化血红蛋白水平均比治疗前明显降低 ,有显著性差异 ;A组胰岛素有效剂量 (38± 12 )IU/d ,显著高于B组胰岛素有效剂量 (30± 10 )IU/d(P <0 .0 5 ) ;2组患者治疗前后血脂无明显变化 ;治疗过程中 ,2组均出现低血糖反应 (A组 4例 ,B组 1例 )。结论　 2型糖尿病磺脲类继发失效时 ,改用胰岛素联用吡格列酮可有效控制血糖 。Objective It is to observe the curative effect and safety of insulin or insulin combined with pioglitazone on type 2 diabetes with sulfonylurea secondum refractoriness. Methods 86 patients with type 2 diabetes with sulfonylurea secondum refractoriness were randomly divided into two groups. Group A were given insulin only and group B were given pioglitazone additionally. The treatment courses were both eight weeks. Results The levels of fasting serum glucose, postprandial 2h blood glucose, saccharifying hemoglobin in all the patients lowered obviously after 8 weeks. Compared with that before treatment, the differences were significant. The effective dosage of insulin in group A was (38±12) IU/d, and it was much more than that in group B which was (30±10) IU/d (P<0.05). The levels of serum lipid in both groups unchanged before and after treatment. Some patients had hypoglycemia reaction (4 cases in group A, 1 case in group B) during treatment. Conclusion Insulin combined with pioglitazone has a better effect on hyperglycemia with less effective dosage and untoward reaction when they are used to treat type 2 diabetes with sulfonylurea secondum refractoriness.

关 键 词：2型糖尿病 磺脲类继发失效 胰岛素 吡格列酮 

分 类 号：R587.1[医药卫生—内分泌]