补肾活血法对2型糖尿病患者血管病变相关因素的影响  

Effects of Kidney-Nourishing and Blood-Activating Therapy on Type 2 Diabetic Vascopathy-Related Factors

作　　者：李鲁扬[1] 孔令均[1] 梁济乐[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《上海中医药杂志》2005年第4期3-5,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：山东省科技厅科研基金资助项目(991205708)

摘　　要：为观察补肾活血法对中老年2型糖尿病患者血管病变相关因素的影响,将50例2型糖尿病患者随机分为治疗组(27例)和对照组(23例)。在原降糖药治疗的基础上,治疗组、对照组分别加服扶正降黏胶囊和复方丹参滴丸,疗程均为2个月。观察患者治疗前后血液流变学、白细胞黏附分子(CD11b/CD18)及血浆内皮素(ET)等指标的变化情况。结果:与治疗前相比,治疗组的多项血液流变学指标、CD11b/CD18、ET、CH、TG均明显降低(P<0. 01,P<0. 05);HDL CH升高(P<0. 01);对照组的数项血液流变学指标、CD11b/CD18、CH等也有明显改善(P<0 .01,P<0. 05)。治疗组在改善患者全血比黏度低切值、血浆比黏度、红细胞刚性指数及凝血因子Ⅰ浓度、血浆ET水平、HDL- CH等方面较对照组更为显著(P<0. 05)。提示补肾活血法预防2型糖尿病患者血管病变的机制可能与其改善血液流变学指标、抑制CD11b/CD18的表达率有关。To observe the effects of kidney-nourishing and blood-activating therapy on type 2 diabetic vascopathy-related factors, 50 subjects were randomized into two groups: treatment group in which 27 cases were treated with hypoglycemic agents and 'Fuzheng Jiangnian Capsule' and control group in which 23 cases were treated with hypoglycemic agents and 'Fufang Danshen Pill'. The blood rheology, CD11b/CD18 and ET before and after treatment were observed. Results: After treatment, some rheologic indexes, CD11b/CD18, ET, TC and TG obviously fell (P<0.01, P<0.05); HDL-CH rose (P<0.01) in both groups; the whole blood low-cut viscosity, plasma viscosity, RBC rigid index, Coagulation factor-Ⅰ, ET and HDL-CH were improved more significantly in treatment group than in control group (P<0.05). It is indicated that this therapy can improve blood rheology and inhibit CD11b/CD18 expression rate to treat diabetic vascopathy.

关 键 词：2型糖尿病血管病变 中西医结合疗法 补肾活血 血液流变学 CD 11b/CD 18 ET 

分 类 号：R259[医药卫生—中西医结合] R587.1[医药卫生—中医内科学]