手性铜催化剂的制备及在环丙烷羧酸酯不对称合成中的应用  

Chiral Copper Complexes for Asymmetric Synthesisof Cyclopropanecarboxylic Esters

作　　者：杨智才[1] 张小微[1] 陈良[1] 

机构地区：[1]华东师范大学化学系

出　　处：《应用化学》1994年第2期70-72,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助课题

摘　　要：３类手性配体ｄ－１０－樟脑磺酸及其衍生物，α－（－）－羟蒎酮及其衍生物，双唑啉衍生物分别与铜（Ⅱ）形成手性铜配合物，催化重氮乙酸酯与１，１－二苯乙烯或异丁烯的环丙烷化加成反应，得到光学活性环丙烷羧酸酯，不对称诱导最高可达９５％ｅ．ｅ．Three kinds of optically active ligands were combined with copper(Ⅱ)-acetate togive 8 chiral copper complexes:d-camphor-10-sulfonic acid and its derivatives of Schiff base,hydroxypinocamphone and its derivatives of Schiff base,and bis-oxazoline. The opticalyields of 2,2-diphenylcyclopropanecarboxylic ethyl ester were 5%～50e.e..The reactionof diphenylethylene or isobutylene with menthyl diazoaceteta by chiral copper(Ⅱ) bis-oxazo-line gave an enantioselectivity of 81.5%e.e. and 95%e.e.,respectively.

关 键 词：手性 铜催化剂 环丙烷羧酸酯 制备 

分 类 号：O643.36[理学—物理化学]