富铬酵母降低高血脂作用的研究  

A STUDY ON THE ANTIHYPERLIPIDEMIC ACTION OF CHROMIUM -ENRICHED YEAST

作　　者：田晓华[1] 庞文贞[1] 赵利民[1] 常红[1] 刘莉[1] 

机构地区：[1]天津医学院营养研究室

出　　处：《营养学报》1994年第2期126-132,共7页Acta Nutrimenta Sinica

基　　金：国家自然科学基金

摘　　要：本文观察富铬酵母（合铬４０ｍｇ／ｋｇ）对高脂血症患者６３人，Ⅱ型糖尿病合并高脂血症患者８２人及血脂正常的Ⅱ型糖尿病人３５人血脂的作用。每日补充２．５ｇ富铬酵母（相当于１００μｇ酵母铬）３个月。以５０例健康成人的有关指标作为对照。结果表明：ａ．６３例高脂血症患者血请铬显著低于健康人（分别为３．５８和５．２７ｎｍｏｌ／Ｌ），服用富铬酵母后，血清铬升高（由３．５８升至６．１０ｎｍｏｌ／Ｌ）。高ＴＣ患者的ＴＣ和高ＴＧ患者的ＴＧ降低，分别为６．３５与５．３４ｍｍｏｌ／Ｌ和３．０５与２．２４ｍｍｏｌ／Ｌ，且ＬＤＬ－Ｃ降低，ＨＤＬ－Ｃ升高，与服药前比较均有显著性差异。降脂效果优于月见草油。合并Ⅱ型糖尿病的高脂血症患者服用富铬酵母后，血清Ｃｒ、ＴＣ、ＴＧ、ＬＤＬ－Ｃ和ＨＤＬ－Ｃ也有相似的变化，且有显著性差异。ｂ．富铬酵母（少数人加服２．５～５ｍｇ优降糖辅助）治疗Ⅱ型糖尿病合并高脂血症患者，其降脂降糖效果优于单纯使用口服降糖药，且过氧化脂质较治疗前显著降低（由６．９０降至５．５１μｍｏｌ／Ｌ）。血脂正常的Ⅱ型糖尿病人服用富铬酵母后除空腹血糖显著降低及ＨＤＬ－Ｃ显著升高外，ＴＣ、ＴＧ及ＬＤＬ－Ｃ均无明显变化。ｃ．富铬酵母对高脂?ixty three hyperlipidemic, eighty two NIDDM complicated with hyper-lipidemia and thirty fivc NIDDM patients with normal blood lipids were given 100μg Cr daily in the form of chromium-enriched yeast for three months.As a control group,sixteen hyperlipidemic patients were given 4g oenotheria binnis seed oil daily for three months. The blood lipidsand serum Cr were measured before and after the supplementation ofchromium-enriched yeast or oenotheria binnis seed oil.Blood lipids and serum Cr of normal adults were estimated too.The results showed that the serum Cr in hyperlipidemic patients was lower obviously than in healthy people(3.58 vs 5.27nmo1/L).After sup-plementation of chromium-enriched yeast, for hyperlipidemic patients,serum Cr increased markedly(3.58 vs 6.10nmol/L),erum TC TG,LDL-C decreased significantly,HDL-Cand HDL_2-C increased obviously;for hy-perlipidemic patients complicated with NIDDM,there were similar changes in serum Cr,TC,TG,LDL-C,HDL-C and HDL_2-C and serum LPO der-eased significantly;for diabetics with normal blood lipids,only FBG decr-eased and HDL-C increased significantly, TC, TG and LDL-C didn′tchange markedly,But there were no apparent differences in TC,TG,LDL一C,HDL-C and serum Cr in those hyperlipidemic patients who weregiven oenotheria binnis seed oil The effective rates were 97.4%, 97.6%,100%and97.6%to high TC,TG,LDL-C and low HDL-C respectively inhyperlipidemic patients. The study demonstrated that chromium-enriched yeast can regulateserum lipids,decreased TC,TG,LDL-C and in creased HDL-C and HDL_2-Cin hyperlipidemic patients and the lipids were maintained at the normalvalue while FBG decreased significantly when it was given to the NIDDMwith normal blood lipids.

关 键 词：富铬酵母 高血脂病 糖尿病 血清络 

分 类 号：R589.2[医药卫生—内分泌]