大动脉脉压与冠状动脉病变严重程度的相关性研究  

Study on relationship between aortic pulse pressure and severity of coronary heart disease

作　　者：王凤群[1] 贾永平[2] 吕吉元[2] 高宇平[2] 王睿[2] 

机构地区：[1]太原钢铁公司总医院,030003 [2]山西医科大学第一医院

出　　处：《山西医药杂志》2005年第4期273-275,共3页Shanxi Medical Journal

基　　金：山西省教育厅高校科技研究开发项目(2 0 0 4 10 11)

摘　　要：目的　探讨有创大动脉脉压(PP)水平与冠状动脉病变严重程度的关系。方法　对15 6例入选病例均行冠状动脉造影术。冠状动脉的严重程度用冠状动脉病变的血管支数及Gensini积分表示。所有病例均在术中测量主动脉血压。结果　高血压组较非高血压组冠心病患病率明显增高(73 .6 %vs 5 8. 5 % ,P =0 .0 32 )。高血压组患者冠状动脉三支血管病变的患病率(35. 2 %vs12 .3% )显著高于非高血压组(P =0 .0 0 1)。冠状动脉狭窄组,主动脉测压其收缩压(SBP)、PP均显著高于冠状动脉正常组,差异有统计学意义(P <0. 0 5 ) ,且SBP与PP随着狭窄支数的增加而逐渐增加。多因素分析结果显示,大动脉PP、年龄、高血压病史与冠心病冠状动脉狭窄程度的关系最为密切。结论　大动脉PP是冠心病冠状动脉狭窄发生发展的独立危险因素。Objective To evaluate the relation of the pulse p ressure (PP) to the severity of coronary arteryial disease.Methods One hundred and fifty-six patients were enrolled.All the patients underwent coronary angiography,The severity of coronary arterial lesions was evaluated by the count of diseased arteries and Gensini score.Aortic SBP (systolic blood pre ssure) and DBP (diastolic blood pressure) were measured at the time of coronary angiography.Results Patients with essential hypertension had hi gher incidence of coronary heart disease (76.9% vs 61.5%, P=0.038) than those without essential hypertension.Patients with essent ial hypertension had a higher incidence of three diseased coronary arteries (35. 2% vs 12.3%,P=0.001) than those without essential hypertension.Aortic SBP and PP were all significantly higher in patients with co ronary arterial disease than in the normal subjects.Multiple regression analysis indicated that aortic PP,age and hypertension were the best predictor for the s everity of coronary lesions.Conclusion Aortic PP is an independen t risk factor to coronary arterial disease and the severity of coronary arterial stenosis.

关 键 词：病变严重程度 大动脉 相关性研究 脉压 冠状动脉狭窄程度 冠状动脉造影术 高血压组 冠状动脉病变 独立危险因素 高血压病史 入选病例 血管支数 动脉血压 病患病率 血管病变 分析结果 发生发展 冠心病 PP 收缩压 主动脉 

分 类 号：R541.4[医药卫生—心血管疾病]