^(188)Re-NEPTDD的制备及生物分布研究  

Preparation of ^(188)Re-NEPTDD and its biodistribution

作　　者：王文进[1] 罗顺忠[1] 何佳恒[1] 王关全[1] 杨玉青[1] 魏洪源[1] 蒋树斌[1] 邴文增[1] 蒲满飞[1] 刘国平[1] 

机构地区：[1]中国工程物理研究院核物理与化学研究所,绵阳621900

出　　处：《核技术》2005年第4期305-308,共4页Nuclear Techniques

基　　金：中国工程物理研究院军民两用资助项目(JM2000201)

摘　　要：在首次合成NEPTDD(2,2,9,9-四甲基-4,7-二氮-4-乙撑哌啶-1,10-二硫癸烷)的基础上,采用SnCl2作还原剂制备了Re-NEPTDD。研究了Re-NEPTDD的生理盐水溶液通过尾静脉注射后在小鼠体内的生物分布188188及该配合物的碘化油溶液通过肝动脉灌注后在大白兔体内的生物分布;用SPECT扫描得出配合物的碘化油溶液通过肝动脉灌注后的大白兔全身显像。实验结果表明,188Re-NEPTDD具有理想的肝摄取,肝部的摄取和滞留较为主要,肝部显像清晰,非靶组织(特别是肺)的摄取和滞留低。On the basis of first synthesizing NEPTDD (2,2,9,9-tetramethyl-4, 7-diaza-4-piperidinyl-ethyl-1, 10-decanedithiol), 188Re-NEPTDD was prepared with SnCl2 as the reducing agent. The biodistribution of 188Re-NEPTDD injected through the tail vein into normal mice and that of lipiodol solution of 188Re-NEPTDD injected through the hepatic arteries into rabbits were studied, and the whole body imaging of rabbit after injecting the lipiodol solution was performed. The results showed that liver uptake of 188Re-NEPTDD was the highest and uptakes in other organs were relatively lower.

关 键 词：^188RE NEPTDD 肝癌 生物分布 

分 类 号：R817.9[医药卫生—影像医学与核医学]