特异性免疫治疗对哮喘患儿的免疫干预作用及肺功能的影响  

Effect of Specific Immunotherapy on Immune and Pulmonery Function of Children with Asthma

作　　者：王成秀[1] 符州[2] 龚财惠[2] 王莉佳[2] 罗健[2] 

机构地区：[1]重庆涪陵中心医院儿科,重庆408000 [2]重庆医科大学附属儿童医院,重庆400014

出　　处：《实用儿科临床杂志》2005年第4期315-317,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨特异性免疫治疗(SIT)对哮喘患儿Th1/Th2及肺功能的影响。方法哮喘发作期患儿43例随机分为A组28例(加用SIT治疗),B组15例(对照组)。在SIT前和SIT后6个月对患儿进行过敏原皮试并检测血IL4和IFNγ、IgE、肺功能,进行临床疗效评价。结果A组SIT后血浆总IgE、尘螨特异性IgE、血清IL4下降,而IFNγ及IFNγ/IL4比值升高;两组肺通气功能均明显改善。A组总有效率92.86%,B组80.00%,两组比较无差异(F=1.56P>0.05)。结论SIT可促进Th2向Th0转化,恢复Th1/Th2平衡,SIT可明显改善肺通气功能。Objective To observe the effect of specific immunotherapy(SIT) on immune and pulmonery function in children with asthma.Methods Forty-three asthmatic children(group A of 28 cases with SIT,group B of 15 cases as controls) were studied.Their skin test,pulmonery function,the levels of IL-4,IFN-γ in PBMCs and total IgE in plasma were detected before and after 6 monthes treatment with SIT.Results Compared with group B,the plasma total IgE and derpspecific IgE in group A were significantly decreased after SIT,IL-4 production significantly dropped,IFN-γ and IFN-γ/IL-4 ratio increased,pulmonery function of both groups were obviously improved.Eeffective ratio was 92.86% in group A and group B was 80.00%(F=1.56 P>0.05).Concusions There exsits the disequilibrium of Th1/Th2 in asthmatic children,but SIT can recovery the balance of Th1/Th2.We find excllent effects of SIT on immune and pulmonery function of asthmatic infants.

关 键 词：哮喘 TH1/TH2亚群 特异性免疫治疗 肺功能:免疫球蛋白E 

分 类 号：R725.6[医药卫生—儿科]