新生儿疾病甘胆酸、透明质酸、Ⅲ型前胶原的变化  

Changes of Serum Glycocholicacid,Hyaluronic Acid,Procollagen Type Ⅲ in Neonatal Diseases

作　　者：盛玮[1] 王德志[1] 陈云龙[1] 方元勋[1] 程士樟[1] 

机构地区：[1]安徽省黄山市人民医院儿科,安徽黄山245000

出　　处：《实用儿科临床杂志》2005年第4期342-343,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨新生儿疾病甘胆酸(CG)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)检测的临床意义。方法应用放射免疫分析法测定49例新生儿疾病患者血清CG、HA、PCⅢ含量,20例出生健康新生儿作对照。结果疾病组血清CG、HA水平较正常对照显著升高(P<0.01,<0.05),而PCⅢ两组无差异,90%以上呈高水平状态。结论联合检测血清CG、HA水平变化对判断新生儿疾病的严重程度和预后有重要参考价值;PCⅢ检测结果不能为诊断提供依据。Objective To investigate the changes of serum glycocholicacid(CG),hyaluronic acid(HA),procollagen type Ⅲ(PCⅢ) in neonatal diseases.Method The levels of serum CG,HA and PCⅢ were measured by radioimmunoassay in 46 neonates with different diseases and 20 healthy neonates.Results Serum CG and HA in patients group were significant higher than those in healthy control group(P<0.01,<0.05).There was no significant difference in PCⅢ between the patients and controls.Conclusion The levels of CG and HA have clinical significance in evaluating the severity and prognosis of neonatal diseases,but there is no value of PCⅢ on diagnosing neonatal diseases.

关 键 词：婴儿 新生 甘胆酸 透明质酸 Ⅲ型前胶原 放射免疫测定 

分 类 号：R722.1[医药卫生—儿科]