含左旋氧氟沙星方案治疗煤工尘肺结核50例分析  

An analysis of the treatment scheme of 50 3 HRZEV/9HREV on coal worker’s pneumoconiosis-tuberculosis

作　　者：韩素敏[1] 陈安启[1] 

机构地区：[1]安徽省淮北矿业集团公司职防院,235000

出　　处：《临床肺科杂志》2005年第3期298-300,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的　观察含左旋氧氟沙星方案治疗煤工尘肺结核复治病例的疗效。方法　采用3HRZEV/ 9HREV治疗煤工尘肺结核50例,观察3个月、1 2个月痰菌阴转率和1 2个月X线胸片好转率;随访一年痰菌复阳率和X线胸片恶化率,并与应用3SHRZ/9HRE方案治疗的75例复治病例作比较。结果　治疗3个月,两组病例痰菌阴转率无差异(P >0 .0 5) ;1 2个月痰菌阴转率、X线胸片好转率均有明显差异(P <0 .0 1 ) ,但对于毁损肺患者疗效两组均差(P >0 .0 5)。讨论　含左旋氧氟沙星方案(3HRZEV/ 9HREV)对于毁损肺以外的各个类型的煤工尘肺结核近远期疗效较满意,值得推广。Objective To explore the therapeut ic effects of levofloxacin (the treatment scheme of 3HRZEV/9HREV) for the coal wor kers’ pneumoconiosis-tuberculosis retreatment. Methods The therapeutic effects and the anti-tuberculosis treatment were compared between th e patients given 50 3HRZEV/9HREV and with 75 3SHRV/9HRE. The variables for the comparision included the sputum tubercle bacillus negative convertion-rate 3 mon ths after the treatment and that after the course of treatment and the reduction -rate of chest X-ray after the course of treatment. After one year’s observati on, the sputum tubercle bacillus positive convertion-rate and in the reduction-r age of chest X-ray were both examined. Results After the 3- month treatment, the 2 groups were not different in the sputum tubercle bacillus negative convertion-rate on all patients (P>0.05), but there were obviously dif ferent in the sputum tubercle bacillus negative convertion-rate and the reductio n-rate of chest X-ray after the course of treatment (P<0.01). After one year’s observation, the treatment group is lower than the control group in both the sp utum tubercle bacillus positive convertion-rate and in the reduction-rate of che st X-ray (P<0.01). However, for the desforied pneumoconiosis-tuberculosis there was little different (P>0.05) between the two. Conclusion T he treatment scheme of the 3HRZEV/9HREV is appropriate to apply on the retreamen t of all kinds of the coal worker’s pneumoconiosis-tuberculosis cases apart fro m the destoried pneumoconiosis-tuberculosis. Its therapeutic effect is quite s atisfactory, so it is worth of being a wider use.

关 键 词：煤工尘肺 结核 左旋氧氟沙星 肺/药物疗法 

分 类 号：R521[医药卫生—内科学]