人精浆中微量蛋白水平与男性生育关系的研究  

REARCH ON THE RELATIONSHIP BETWEEN THE CONTENT OF MICRO-PROTEINS AND SPERMATIC SERUM AND MALE FERTILITY

作　　者：李向东 张纪云[2] 

机构地区：[1]临沂兰山区第一人民医院,山东临沂276002 [2]临沂医学专科学校

出　　处：《临沂医学专科学校学报》2005年第1期5-9,共5页Journal of Linyi Medical College

摘　　要：目的　 探讨人精浆中白蛋白 (Alb)、β2 - 微球蛋白 (β2- MG)、α1 -微球蛋白 (α1- MG)、TH糖蛋白 (THP)、免疫球蛋白G(IgG)、分泌型免疫球蛋白A(SIgA)、铁蛋白 (Fer)等各种微量蛋白与男性生殖之间的关系。方法　 应用放射免疫分析技术对 12 5例不育症和 2 2例生育者精浆中Alb、β2 - MG、α1- MG、THP、IgG、SIgA、Fer等各种微量蛋白水平进行了检测 ,并分析了精浆中各种微量蛋白浓度与精液中精子密度及功能之间的关系。结果　 不育症组精浆中Alb、β2 - MG、-α1 MG、THP、IgG、SIgA含量均低于生育组 ,除THP含量外 ,其余各项在两组之间均存在显著性差异 (P <0 .0 5或P<0 .0 1) ;不育症组精浆中Fer含量显著高于生育组 (P <0 .0 1)。并且在不育症组中精浆Alb、β2 MG、α1 MG、Fer、THP含量均与精子密度成正比 ,精液中精子的活动能力与精浆中Alb、β2 MG、-α1 MG、Fer含量亦存在一定关系 ,不育症各组精浆中SIgA和IgG含量均明显低于正常生育者。精浆中Alb浓度与精子密度、精子活动率、精子存活率、正常精子比率 ,以及精子毛细管穿透力、精子尾部肿胀率和精子顶体完整率等指标之间存在显著相关性 (P <0 .0 1)。结论　 精浆中微量蛋白的含量与男性的生殖能力有关 。Objective To explore the relationship betwee n male fertility and the contents of micro-proteins such as Alb,β 2-MG, α 1 -MG,THG,IgG,SigA and Fer.Methods The contents of such micro-pro teins as mentioned above in the spermatic serum of 125 cases of sterility and 22 cases of fertility were determined through RIA. The relationship between the co ntents of those micro-proteins and the concentration of sperm in serum was anal yzed.Results The contents of Alb, β 2-Mg, α 1-MG, IgG and S IgA in the group of sterility were found lower than those in the group of fertil ity(P<0.05 or P<0.01) with the content of THG being an exception. The co ntent of Fer was higher in sterility cases than in fertility cases (P<0.01). The contents of Alb,β 2-MG,α 1-Mg, fer, THG were in direct proportion to the sperm concentration.The activity of sperm also had some relation to the cont ents of Alb, β 2-MG, α1-MG and Fer. The contents of SIgA and IgG were much lower in the group of sterility than in the normal group. There existed remarkab le correlation between the content of Alb and such indexes as sperm concentratio n, the rate of spermatic activity,survival rate of sperm, the content of normal sperm, capillary penetrating power of sperm, the swelling rate of sperm end part s and the acrosomal intact rate(P<0.01).Conclusion Male ferti lity is closely related to the contents of micro-proteins in spermatic serum. T he determination of the contents of Alb, β 2-MG,α 1-MG, fer, SIgA and IgG can help to detect the conditions of sterility cases and can be instructive in c linical treatment.

关 键 词：男性生育 精浆 微量蛋白 

分 类 号：R698.2[医药卫生—泌尿科学]