桂枝汤降压作用机制初探——对血浆及组织中ET,NT含量的影响  

Mechanism of Guizhi decoction on lowering blood pressure in SHRs--effects on ET and NT contents in SHR plasma and tissues

作　　者：刘婷[1] 张毅[1] 秦彩玲[1] 孙玉茹[1] 孙有富[1] 姜廷良[1] 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国药学杂志》2005年第6期421-423,共3页Chinese Pharmaceutical Journal

基　　金：国家"九五"攀登项目"中药现代化关键问题的基础研究资助项目"(790211018)

摘　　要：目的研究桂枝汤降压的作用机制。方法采用放免法,观察桂枝汤全方及其降压有效部位E(Fr.E)对自发性高血压大鼠(SHR)血浆、下丘脑及主动脉中内皮素(ET)、神经降压素(NT)含量的影响。结果Fr.E能明显对抗SHR主动脉中ET含量的升高及下丘脑中NT含量的下降;桂枝汤全方能明显降低SHR主动脉中ET含量的升高。结论桂枝汤及Fr.E对上述血管活性物质的影响可能是其降压作用的机制之一。OBJECTIVE: To investigate the mechanism of Guizhi decoction on lowering blood pressure in SHRs. METHODS: By radioimmuno-precipitation assay, the contents of ET and NT in SHR plasma, hypothalamus and aorta were measured after Guizhi decoction and active fraction (Fr. E) were administered, respectively. RESULTS: Fr. E administered orally obviously decreased the content of ET in SHR arota, increased NT content in hypothalamus and Guizhi decoction decreased the content of ET in SHR arota. CONCLUSION: Guizhi decoction and Fr. E decreased blood pressure in SHRs by effecting the contents of ET and NT.

关 键 词：桂枝汤 有效部位 自发性高血压大鼠 内皮素 神经降压素 

分 类 号：R285.5[医药卫生—中药学]