胰岛素口服缓释给药系统的制备  

Preparation of oral sustained-release system of insulin

作　　者：石海涛[1] 张志荣[1] 龚涛[1] 刘世伟[1] 陈蜀[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第2期101-104,共4页West China Journal of Pharmaceutical Sciences

基　　金：国家 8 63计划资助项目 (2 0 0 3AA2 170 10 )

摘　　要：目的　探索构建蛋白类药物口服缓释给药系统的方法。方法　制备多孔羟基磷灰石载药微球。控制Eudragit○RL - 1 0 0包衣微球的粒径或将其渗入羟基磷灰石载药微球孔洞的程度进行构建。结果　两种方法构建的给药系统都具有缓释效果。结论　有望成功构建蛋白类药物口服缓释给药系统。OBJECTIVE To fabricate the oral sustained-release system of proteinic drug. METHODS With insulin-adsorbed porous hydroxyapatite microspheres, two strategies have been explored to achieve this goal: preparing different sizes of insulin-adsorbed hydroxyapatite microspheres or different degrees of EudragitD○R L-100 immersion into the cavities of hydroxyapatite microspheres. RESULTS In vitro studies of drug release demonstrated that the systems fabricated with mentioned strategies both had sustained-release effect. CONCLUTION There is possibility of fabricating oral sustained-release system of proteinic drug.

关 键 词：羟基磷灰石 胰岛素 多肽 蛋白类药物 缓释 

分 类 号：TQ464.7[化学工程—制药化工]