黄藤素缓释片释放度的测定及其释药特性  

In vitro the release characteristics of sustained-release palmatine tablet

作　　者：金朝辉[1] 蒋学华[1] 徐伟娟[1] 陈卓[1] 袁子雁[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第2期113-115,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的　进行黄藤素缓释片释放度的测定及释药规律的研究。方法　采用紫外分光光度法测定黄藤素缓释片的释放度,并进行释药规律的研究。结果　测定波长为342nm ,黄藤素在3. 0～1 0 . 0 μg·ml-1 范围内线性关系良好(r =0 . 9999)。其体外释放特性符合Higuchi模式。结论　黄藤素缓释片释药机理是扩散和骨架溶蚀协同作用,而非单纯Fick扩散。OBJECTIVE To investigate the determination method of sustained-release palmatine tablet in vitro and study the releasing mechanism. METHODS The dissolution rate of palmatine sustained-release tablets was determined by UV spectrophotometry,and release regularity was investigated. RESULTS 342 nm was selected as the determination wavelength,and in the range of 3.0-10.0 μg·ml -1, the concentration is linearly proportional to the absorption of palmative.Higuchi model was selected as the description of the sustained-release Palmatine tablet's releasing mechanism.CONCLUSION Palmatine tablet is non-Fick diffusion that drug diffusion and matrix corrosion are synergetic.

关 键 词：黄藤素 缓释片 释放度 释药特性 

分 类 号：R283.6[医药卫生—中药学]