Labrasol对肠P-糖蛋白功能的影响  

In vitro modulation of intestinal P-glycoprotein function by labrasol

作　　者：林玉莲[1] 蒋学华[1] 杨俊毅[1] 周静[1] 张铃敏[1] 山本昌 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]日本京都药科大学药剂学教室,日本京都6078414

出　　处：《华西药学杂志》2005年第2期139-142,共4页West China Journal of Pharmaceutical Sciences

摘　　要：目的　研究Labrasol对肠P -糖蛋白功能的影响。方法　用大鼠的离体肠段,通过体外Ussingchamber的转运实验,研究了Labrasol对P -糖蛋白底物若丹明1 2 3转运的影响,同时考察了非P -糖蛋白底物荧光黄在Labrasol作用下的转运行为。结果　低浓度(0 .0 5 %～0 .0 75 %)的Labrasol能够抑制回肠与结肠中P -糖蛋白的功能。同时,对荧光黄的转运无显著影响。结论　Labrasol有望作为P -糖蛋白抑制剂,用于改善受P -糖蛋白介导药物的吸收,提高口服药物的生物利用度。OBJECTIVE To investigate the effects of the Labrasol on the function of the intestinal P-glycoprotein(P-gp).METHODS The isolated rat intestinal membranes were used to study the effects of Labrasol on the transportation of Rhodamine123(a subtrate of P-gp) and Lucifer yellow(non-subtrate of P-gp )by ussing chamber.RESULTS Labrasol in low concentration(0.05%～0.075%) can affect the transportation of Rodamine123,but has no effect on Lucifer yellow in ileum and colon.CONCLUSION Labrasol can inhibit the function of P-gp in ileum and colon, thereby increasing intestinal absorption and bioavailability of various drugs.

关 键 词：P-糖蛋白 LABRASOL Ussing CHAMBER 荧光黄 若丹明123 

分 类 号：R96[医药卫生—药理学]