混合促透剂对肤康涂膜剂中水杨酸和酮康唑透皮效果的影响  

The Effect of Mixed Transdermal Enhancers on Percutaneous Absorption of Salicylic Acid and Ketoconazole in Fukang Balm

作　　者：盛国荣[1] 

机构地区：[1]江苏省南通市疾病控制中心皮防所,江苏南通226006

出　　处：《中国药业》2005年第4期29-31,共3页China Pharmaceuticals

摘　　要：目的:考察混合促透剂月桂氮酮和薄荷脑对肤康涂膜剂中水杨酸和酮康唑透皮促进作用的影响。方法:采用简单小室法,以离体雄性大鼠皮肤为透皮屏障,用高效液相色谱法测定体外接受液中水杨酸和酮康唑的含量,计算各时间点的累积透皮率。结果:含2%月桂氮酮和2%薄荷脑的涂膜剂与不含月桂氮酮的涂膜剂相比较,其透皮促进作用在6h后则呈显著性差异(P<0.01)。结论:不同浓度的混合促透剂均可不同程度地提高水杨酸和酮康唑的透皮促进作用,其中以2%月桂氮酮和2%薄荷脑组成的混合促透剂作用最显著。Objective:To observe the effect of mixed transdermal enhancers of azone and menthol on percutaneous absorption of salicylic acid and ketoconazole in Fukang balm.Methods:Using the simple cell method,the isolated skin of male mice as transdermal barrier,the transdermal amount of salicylic acid and ketoconazole in different concentration of mixed azone and menthol was dertermined by HPLC.Results:Comparing with the balm which contains no azone,the balm containing 2%azone and 2%menthol showed a remarkable difference(P < 0.01) after 6 hours.Conclusion:It was demonstrated that various transdermal enhancers could promote absorption of salicylic acid and ketoconazole in Fukang balm in different level and the enhancer of 2%azone and 2%menthol was the most effective one.

关 键 词：肤康涂膜剂 月桂氮ZHUO酮 薄荷脑 水杨酸 酮康唑 透皮效果 

分 类 号：R965[医药卫生—药理学] R944.1[医药卫生—药学]