穿琥宁注射液治疗流行性乙型脑炎疗效观察  

Therapeutic Efficiency of Potassium Dehydroandrographolide Succinate Injection for Treating Epidemic Encephalitis B

作　　者：刘泽明[1] 郭大为[1] 陈文[1] 

机构地区：[1]泸州医学院附属医院,四川泸州646000

出　　处：《寄生虫病与感染性疾病》2004年第3期103-105,共3页Parasitoses and Infectious Diseases

摘　　要：目的　观察穿琥宁注射液对乙脑患儿的治疗效果。方法　将 98例病例随机分为治疗组和对照组 ,治疗组 5 2例 ,在传统治疗的基础上加用穿琥宁注射液 5～ 1 0 mg/( kg· d) ;对照组 ( 4 6例 )加用病毒唑 1 0～ 1 5 mg/( kg·d) ;均静脉滴注 ,1次 /d,疗程 5～ 7d。比较两组疗效及主要临床症状改善时间。结果　治疗组 :治愈率80 .77% ,总有效率 94.2 3 % ;对照组 :治愈率 60 .87% ,总有效率 84.78%。两组治愈率比较差异有显著性 ( P<0 .0 5 ) ,但总有效率比较差异无显著性 ( P>0 .0 5 ) ;穿琥宁在降低体温方面 ,明显优于对照组 ( P<0 .0 1 ) ,且患儿抽搐停止、神志转清、脑膜刺激征缓解等时间均短于对照组 ( P<0 .0 5 )。结论　乙脑患儿在传统治疗的基础上加用穿琥宁注射液治疗 ,有利于改善临床症状 ,提高治愈率。Objective To observe the therapeutic effeciency of potassium dehydroandrographolide succinate injection to epidemic encephalitis B patients. Method 98 epidemic encephalitis B patients were randomly divided into Treatment Group(n=52) and Control Group(n=46). In addition to usual therapy, the Treatment Group was treated with potassium dehydroandrographolide succinate injection (5~10 mg/kg·d, qd) and Control Group with ribavirin (10~15 mg/kg·d,qd) for 5～7 days. Results There were significant differences (P< 0.05) in cure rates between Treatment Group (80.77%) and Control Group (60.87%) but there were no significant differences (P>0.05) in total effective rates (94.23% and 84.78%). As compared with the Control Group, potassium dehydroandrographolide succinate injection was markedly better in reducing fever (P<0.01) and in improving major clinical symptoms, such as improving convulsion, vague mind, meningeal irritation signs and symptoms (P<0.05). Conclusion In addition to usual therapy, potassium dehydroandrographolide succinate injection could rapidly improve clinical symptoms and increase the cure rate in endemic encephalitis B patients.

关 键 词：流行性乙型脑炎 穿琥宁注射液 疗效观察 

分 类 号：R512.32[医药卫生—内科学]