固本消瘤胶囊抑制小鼠Lewis肺癌生长及抗血管生成研究  

Inhibitory Effect and Antiangiogenesis of Gubenxiaoliu Capsule on Lewis Lung Carcinoma of Mouse

作　　者：杨国旺[1] 王笑民[1] 王征[2] 彭瑞云[3] 高亚兵[3] 王晓民[3] 

机构地区：[1]北京中医医院,北京100010 [2]中国医学科学院肿瘤研究所,北京100021 [3]军事医学科学院二所,北京100850

出　　处：《中国实验方剂学杂志》2004年第5期50-52,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的 :探讨中药固本消瘤胶囊对小鼠Lewis肺癌抑瘤作用及机制。方法 :体内动物实验观察小鼠肿瘤生长 ;免疫组化染色S P法、病理彩色图像定量分析法检测小鼠肿瘤组织中微血管密度 (MVD)、血管内皮生长因子 (VEGF)表达。结果 :中药组、化疗组、中药加化疗组对小鼠Lewis肺癌抑制率分别为为 4 0 5 %、5 2 6 9%、6 1 0 9% ,与对照组比较有显著差异 (P <0 0 1)。中药组、中药加化疗组MVD、VEGF表达水平以及化疗组MVD水平明显下降。结论 :固本消瘤胶囊对小鼠Lewis肺癌有明显抑制作用 。Objective:To explore the inhibitory effect of tumor growth and antiangiogenesis of Gubenxiaoliu capsule(GC) on Lewis lung carcinoma of mouse.Methods:In vivo animal experiment was used to investigate the growth of mouse tumor.Immunohistochemically(S P) and quantitative pathologic image analysis were used to investigate the microvesel dencity(MVD) and expression of vascular endothelial growth factor(VEGF) in tumor tissue.Results:The inhibitory rates on mouse tumor of GC group,Chemotherapy group and GC+Chemotherapy group are 40 58%, 52 69%, 61 09% respectively,The inhibitory rates are significantly higher than the control,MVD and expression of VEGF of GC group and GC+Chemotherapy group and MVD of Chemotherapy group decreased significantly.Conelusion:GC could inhibit the growth and angiogenesis of Lewis lung carcinoma of mouse.

关 键 词：固本消瘤胶囊 肺癌 免疫组化 

分 类 号：R285.5[医药卫生—中药学]