伊贝沙坦治疗原发性高血压疗效的影响因素分析  

Risk factors of Irbesartan in treatment of essential hypertension

作　　者：肖琴[1] 臧桐华[1] 徐希平[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032

出　　处：《疾病控制杂志》2005年第2期134-136,共3页Chinese Journal of Disease Control and Prevention

基　　金：安徽省教育厅自然科学研究项目(2 0 0 2kj174ZC)

摘　　要：目的　分析伊贝沙坦治疗原发性高血压疗效的影响因素,探讨高血压病个体化医疗的途径。方法　经过两次筛检,共有90 9例研究对象入选前瞻性研究队列,其中82 8人完成全程随访。对服用伊贝沙坦产生的疗效进行测量,并对相关因素进行分析。结果　单因素分析结果显示:体重、体重指数、胸围、腰围、腰臀比、每周食用蔬菜量与伊贝沙坦降压疗效有关。多因素分析结果显示:腰臀比、每周食用蔬菜量、体重指数、每周体育锻炼次数对伊贝沙坦降压疗效有显著影响。结论　生活习惯和个体特征可影响伊贝沙坦的降压疗效,这些因素可为实施个体化医疗提供依据。Objective To evaluate the risk factors of Irbesartan in treatment of essential hypertension and to explore individualized antihypertensive treatment. Methods After two screenings, 909 subjects entered the prospective study cohort, and 828 of them finished the study. The risk factors of Irbesartan in treatment of hypertension were evaluated. Results Result of univariate analysis showed that the risk factors of Irbesartan in treatment of essential hypertension were weight, body mass index (BMI), chest circumference, waist line, waist hip ratio (WHR), quantity of vegetable taken in every week. But stepwise regression analyses showed the risk factors were WHR, quantity of vegetable taken in every week, taking regular exercise and BMI. Conclusions Individualized antihypertensive treatment to hypertension should be adopted.

关 键 词：高血压 血管紧张素转换酶抑制药 治疗 影响因素 

分 类 号：R544.1[医药卫生—心血管疾病]