高血压患者胰岛素抵抗与凝血系统功能的关系  

Correlation between insulin resistance and coagulation in patients with hypertension

作　　者：林树无[1] 马晶茹[1] 及跃[1] 张湘兰[1] 邹丹[1] 

机构地区：[1]沈阳医学院附属第二医院心内科,辽宁沈阳110002

出　　处：《心血管康复医学杂志》2005年第2期129-130,126,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究高血压(EH)患者胰岛素抵抗(IR)与凝血系统功能的关系。方法:按75g葡萄糖口服负荷法(OGTT)结果,69例EH患者被分为糖耐量正常(NGT)组(43例)例和糖耐量异常(IGT)组(26例)。另正常对照组31例。测定各组纤维蛋白原(Pg)、纤溶酶原激活物抑制因子(PAI-1)含量,同时作血胰岛素(INS)测定, 用HOMA指数作为胰岛素抵抗指标。结果:高血压两组与正常对照组相比HOMA指数、Fg、PAI-1水平明显异常(P<0.05～<0.01).高血压IGT组的这些指标较高血压NGT组更恶化(P<0.05～<0.01)。HOMA与PAI-1、Fg 之间具有正相关性,其r分别为0.635,0.832。结论:高血压病人存在胰岛素抵抗和凝血异常,当高血压合并IGT时, 胰岛素抵抗更严重,血液促凝血状态加重。Objective:To investigate the relationship between insulin resistance (IR) and activation of coagulation system in patients with hypertension. Methods:Plasma plasminogen activator inhibitor type-1(PAI-1),fibrinogen (Fg) were measured. Oral glucose tolerance test (OGTT),insulin release test(IRT) were performed. IR was estimated by homeostasis model assessment (HOMA). Three groups of subjects were categorized as followings: Forty-three hypertension patients with normal glucose tolerance (NGT). 26 patients with impaired glucose tolerance (IGT) and 31 healthy subjects as control. Results:Compared with control group the levels of HOMA, PAI-1, Fg were markedly abnormal in both IGT and NGT groups (P<0. 05-<0. 01);while the most significant changes were found in patients of IGT (P<0. 05-<0. 01), compared with NGT group. Posetive correlation was shown among HONA and PAL-1, Fg (r=0. 635, 0. 832 respectively). Conclusion: Patient with hypertension has increased insulin resistance and activation of coagulation system. The most remarkable changes are found in hypertension patients with IGT.

关 键 词：高血压 胰岛素抵抗 凝血系统活性 糖耐量 

分 类 号：R544.1[医药卫生—心血管疾病]