庆大霉素唾液药物浓度测定及临床意义  

Determination of Salivary Drug Concentration of Gentamicin and Its Clinic Significance

作　　者：何晶[1] 

机构地区：[1]大连医科大学附属第四医院,大连市116001

出　　处：《中国药房》2005年第7期527-528,共2页China Pharmacy

摘　　要：目的:探求唾液药物浓度与血药浓度的相关性及临床意义。方法:采用放射免疫法测定15例志愿受试者庆大霉素的唾液药物浓度和血药浓度。结果:血液、唾液中的庆大霉素浓度均在用药后1h达峰。结论:血液、唾液中的庆大霉素浓度呈正相关关系,即在庆大霉素治疗药物监测中唾液有可能代替血液。OBJECTIVE:To study the correlation between salivary drug concentration and blood,drug level its clinic sig-nificance.METHODS:The salivary drug concentration and blood drug level of gentamicin of15volunteer cases were deter-mined by radioimmunoassay.RESULTS:Both blood drug level and salivary drug concentration of gentamicin reached to peak level1hour after medication.CONCLUSION:The blood drug level of gentamicin and the salivary drug concentration of gentamicin are positively correlated,i.e.it is possible for salivary to substitute for blood in the therapeutic drug monitoring of gentamicin.

关 键 词：庆大霉素 唾液药物浓度 血药浓度 

分 类 号：R978.12[医药卫生—药品]