聚丙烯表面的生物相容性修饰:表面氨基放大还原胺化接枝磷酰胆碱  

Surface Amino Amplification and Graft with Phosphorylcholine by Reductive Amination

作　　者：宫永宽[1] WINNIK Francoise M 

机构地区：[1]西北大学化学系,西安710069 [2]加拿大蒙特利尔大学化学系药学院

出　　处：《化学学报》2005年第7期643-647,F009,共6页Acta Chimica Sinica

基　　金：陕西省教育厅专项科研基金(No.04JK146)资助项目

摘　　要：在氨气氛中对聚丙烯薄膜表面进行等离子处理,获得了不同浓度的表面氨基.表面氨基的数量经1,6-己二异氰酸酯键合三(2-氨乙基)胺可成倍增加.用还原胺化法将磷酰胆碱醛共价接枝到表面氨基上获得了磷酰胆碱改性的聚丙烯薄膜.X射线光电子能谱(XPS)测定结果表明,接枝磷酰胆碱基团的表面覆盖率可达20%～40%.衰减全反射傅立叶变换红外(ATR-FTIR)和动态接触角测定结果也都说明磷酸胆碱基团被成功地接枝于聚丙烯表面.还原胺化法结合等离子处理及表面氨基放大技术,有望成为获取新型生物材料的一种有效途径.Polypropylene film surface was grafted with amino groups by using a radio-frequency glowing discharge system fed with ammonia. The number of the surface amino groups was amplified by bonding tris-(2-aminoethyl)amine through the linker of 1,6-diisocyanatohexane. Phosphorylcholine (PC) bearing aldehyde functionality was covalently bonded with the surface amino group by reductive amination. Surface composition was determined by X-ray photoelectron spectroscopy (XPS). The grafted PC groups can cover 20%similar to 40% of the surface. The success of the modifications was also supported by attenuated-total-reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) and dynamic contact angle measurements. These methods of surface amino amplification and the subsequent coupling of PC-containing aldehyde molecules are promising ways of obtaining novel biomaterials.

关 键 词：生物相容性 氨基 X射线光电子能谱(XPS) 胆碱 接枝 还原胺化 等离子处理 修饰 己二异氰酸酯 测定结果 聚丙烯薄膜 表面覆盖率 动态接触角 傅立叶变换 衰减全反射 薄膜表面 放大技术 生物材料 胺化法 碱改性 氨乙基 基团 

分 类 号：O632.12[理学—高分子化学]