中草药减肥致肝损害20例分析  

Hepatotoxicity induced by weight reduction herbs: an analysis of twenty cases

作　　者：汪月娥[1] 王晓今 计焱焱[1] 陈成伟 姚光弼[1] 

机构地区：[1]上海市静安区中心医院,2000040 [2]上海市南京军区临床肝病研究中心

出　　处：《肝脏》2005年第1期27-29,共3页Chinese Hepatology

摘　　要：目的　分析减肥草药所致的肝脏损伤的临床特点 ,提高认识 ,避免盲目服用减肥草药。方法　对 1997～2 0 0 4年收治的 2 0例病人的病因、潜伏期、临床和实验室特点和预后进行分析。结果　 2 0例病人均为女性 ,年龄 18～ 60岁 ,平均 (4 0 .95± 11.5 )岁 ,仅有 6例BMI >2 5 ,余 2 4例均未超重。分别服用市售减肥 (草 )药 11种及中药汤剂 1种。发病潜伏期 9～ 90d ,平均 (3 9.79± 2 4.97)d ,主要症状有乏力、上腹胀、恶心呕吐和尿色深等 ,肝生化检查 :8例血胆红素增高 ,ALT及ALP均增高。临床分型 :肝细胞损伤型 17例 ,胆汁淤积型 2例 ,混合型 1例。停药后临床和肝功能恢复。结论　减肥草药导致的急性肝损害并不少见 ,应予警惕 。Objective To analyse the clinical characteristics of liver injury induced by body weight reduction herbs in order to distinguish the nature and avoid the unjustified use of weight reduction drugs.Method 20 patients were admitted as having drug induced liver disease from 1997 to 2004. Results All were females, 6 patients considered as over body weight (BMI>25).12 kinds of Chinese herbs were included move or less taken by the patients. The incubation period varied from 9 to 90 days(average 39.79±24.97 days). The main features including fatigue, upper abdominal discomfort, nausea, vomiting, dark urine, 8 cases presented with jaundice. Liver chemistry showed elevation of serum ALT and ALP levels. According to an International classification, 17 cases were acute hepatocellular injury type, 2 cases were acute cholestasis type, only one case was mixed type. All patients recovered after discontinuation of the relevant herbs.Conclusion Drug induced liver injury caused by weight reduction herbs is not uncommon, avoiding the unjustifiable use of herbs with unclear property is critical.

关 键 词：中草药 血胆红素增高 2004年 实验室特点 发病潜伏期 胆汁淤积型 急性肝损害 肝功能恢复 临床特点 肝脏损伤 中药汤剂 主要症状 恶心呕吐 生化检查 临床分型 60岁 BMI 损伤型 肝细胞 ALP ALT 停药后 混合型 减肥药 病人 

分 类 号：R595[医药卫生—内科学]