腔内预衬在人工血管内皮化中的应用  

ROLE OF PRE-COATING IN ARTIFICIAL VESSEL ENDOTHELIALIZATION

作　　者：肖乐[1] 时德[1] 

机构地区：[1]重庆医科大学附属第一医院血管外科,重庆400016

出　　处：《中国修复重建外科杂志》2005年第4期270-273,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的　介绍腔内预衬在人工血管内皮化中的应用。　方法　收集近年相关文献并加以综合分析。　结果　腔内预衬包括:化学预衬(胶原、纤维结合素、层粘连蛋白、聚左旋赖氨酸、明胶和细胞外基质等) ,预凝(血浆、血液、血清和纤维蛋白凝胶等) ,化学结合(肝素、精氨酸-甘氨酸-天冬氨酸和植物凝集素)和表面修饰。大多数预衬物都能明显提高内皮细胞黏附。　结论　腔内预衬能促进人工血管内皮化,但对浓度和孵化时间还需进一步研究。Objective To understand the value of pre-coating in artificial vessel endothelialization. Methods Literature concerning pre-coating in artificial vessel endothelialization was extensively reviewed. Results Pre-coating included chemical coatings(collagen, fibronectin, laminin, poly-l-lysin, gelatin and extracellular matrix), pre-clotting(plasma, blood, serum and fibrin glue), chemical bonding (heparin, RGD and lectins) and surface modification. Most of them could enhance the adhesion of the endothelial cells. Conclusion Pre-coating could improve endothelialization, but further research is needed to search for the appropriate concentration and incubation time.

关 键 词：人工血管内皮化 腔内 精氨酸-甘氨酸-天冬氨酸 纤维蛋白凝胶 内皮细胞黏附 纤维结合素 层粘连蛋白 细胞外基质 植物凝集素 综合分析 表面修饰 赖氨酸 预衬物 步研究 化学 

分 类 号：R318.1[医药卫生—生物医学工程]