西安地区肺癌危险因素的病例对照分析  

A case-control study on the risk factors of lung cancer in Xi'an

作　　者：韩勇[1] 王云杰[1] 朱江 卢强[1] 

机构地区：[1]第四军医大学唐都医院胸外科,陕西西安710038 [2]陕西省肿瘤医院胸外科,陕西西安710061

出　　处：《现代肿瘤医学》2005年第2期267-269,共3页Journal of Modern Oncology

基　　金：国家自然科学基金资助(项目编号: 30271461)

摘　　要：　目的　分析西安地区肺癌危险因素,为进一步的肺癌危险因素监测提供依据。方法　对西安地区1999年至2002年12月肺癌病例248例及对照263例按1∶1配对进行病例对照分析,估计各危险因素与肺癌的联系强度。结果　单因素分析的危险因素有吸烟(OR=1. 66)、油烟污染暴露(OR=1. 68)、精神创伤史(OR=1. 80)、家族肿瘤史(OR=2. 08)、呼吸道疾病史(OR=1. 46),其中具有COPD病史的患者,肺癌发生的危险性明显增高(OR=2. 25),肺功能的损伤增加了肺癌发生的危险性, (OR=2. 28)。结论　吸烟、油烟污染暴露、精神创伤史、家族肿瘤史、家族肺癌史、呼吸道疾病史是西安地区肺癌的危险因素。具有COPD病史的患者,肺癌发生的危险性明显增高。肺功能的损伤增加了肺癌发生的危险性。Objective To study the risk factors of lu ng cancer patients in Xi'an. Methods The analysis was based on the data of a case-control study conducted during 1999~2002 in Xi'an, China, and evaluated by the odd ratio (OR). Results Single fact or analysis showed that tobacco smoking(OR=1.66), cooking smoke(OR=1.68), hi story of previous lung diseases(OR=1.46), family history of tumor(OR=2.08), and psychic trauma(OR=1.80)were the main risk factors of lung cancer, however, physical practice and fresh vegetables were the protective factors. Patients wi th COPD had an increased risk of lung cancer (OR=2.25). And the impairment of lu ng function was observed to increase the risk of lung cancer (OR=2.28). Conclusion Smoking, cooking smoke, history of previous lung dise ases, family history of tumor, and psychic trauma are related with lung cancer s ignificantly (P<0.05).The risk of lung cancer increased in the pat ients with a history of COPD, and the impariment of lung function increases the risk of lung cancer.

关 键 词：肺癌 危险因素 病例-对照研究 

分 类 号：R734.2[医药卫生—肿瘤]