脂肪干细胞向神经细胞分化的研究现状  

Current research status of the differentiation from adipose tissue-derived stem cell to neural cell

作　　者：周虎田[1] 徐如祥[1] 姜晓丹[1] 

机构地区：[1]南方医科大学珠江医院神经外科,广州510282

出　　处：《中华神经医学杂志》2005年第3期309-311,共3页Chinese Journal of Neuromedicine

摘　　要：源于中胚层的脂肪与骨髓组织中的干细胞,均具有多向分化潜能,在特殊的环境条件诱导下,可向神经细胞分化。多种物质如氢化考地松、丙戊酸、丁羟茴醚、弗司扣林、表皮生长因子和成纤维细胞生长因子、β-巯基乙醇等可对脂肪干细胞向神经细胞的分化进行调控。脂肪来源的干细胞向神经细胞分化应用于中枢神经损伤功能改变有一定的效果,是值得深入研究的课题之一。The stem cells consist in the adipose and bone marrow tissue originated from mesodermal tissue. They have the differentiation pluripotency and can differentiate into neural cells under special environment. Various materials such as hydrocortisone,valproic acid,butylated hydroxyanisole,forskolin,epidermal growth factor,fibroblast growth factor,β-mercaptoethanol,etc. can modulate it in vitro. The differentiation from the adipose tissue-derived stem cells to neural cells has shown reasonable effect in the functional recovery after central nervous injury, so that it is a worthwhile topic.

关 键 词：神经细胞分化 脂肪干细胞 成纤维细胞生长因子 多向分化潜能 表皮生长因子 中枢神经损伤 β-巯基乙醇 氢化考地松 骨髓组织 环境条件 丁羟茴醚 功能改变 中胚层 丙戊酸 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]