实验大鼠肝性病肠道菌群失调与血氨的关系  

Effect of imbalance of the intestinal flora on ammonia concentrations experimental rats with hepatic encephalopathy

作　　者：高玲娟[1] 杨景云[2] 刘柱[3] 苏亚娟[1] 王淑敏[1] 

机构地区：[1]佳木斯大学 [2]佳木斯大学基础医学院微生物教研室 [3]青岛市第二人民医院检验科

出　　处：《中国微生态学杂志》2005年第2期105-106,共2页Chinese Journal of Microecology

摘　　要：目的　探讨肝性脑病实验大鼠肠道菌群失调对血氨浓度的影响。方法　Wistar大鼠4 0只,随机分为4组,其中3组制备肝性脑病模型,剩余1组为正常对照组,分别以灌胃给药,以需氧、厌氧法及血浆除蛋白滤液法检测肠道菌群及血浆中血氨含量。结果　肝性脑病与正常对照组比较,有明显的肠道菌群失调症,同时伴有血氨浓度显著升高( P<0 .0 5 )。结论　实验大鼠肠道菌群失调可引起大鼠血浆内血氨浓度明显升高。Objective To explore the imbalance of the intestinal flora on ammonia concentrations in experimental rats with hepatic encephalopathy.Mothods Wistar rats was divided into 4 groups randomly.The determination of intestinal flora content by the bacterial culture and ammonia was measured respectively.Result Ammonia concentation in hepatic encephalopathy rats who were imbalance of intestinal flora were higher than normal experimental rats significantly( P <0 05).Conclusion There was an closely related between the imbalance of intestinal flora and the hyperammonia in experimental rats with hepatic encephalopathy.

关 键 词：菌群失调 大鼠肝 Wistar大鼠 肝性脑病 血氨 实验大鼠 氨浓度 肠道菌群 氨含量 血浆 厌氧法 对照 蛋白 

分 类 号：Q485[生物学—生理学] S858.316.4[农业科学—临床兽医学]