6-氰基吲哚-3-甲醛的合成  

Synthesis of 6-Cyanoindole-3-carboxaldehyde

作　　者：葛裕华[1] 吴亚明[1] 薛忠俊[1] 

机构地区：[1]东南大学化学化工系,南京210096

出　　处：《应用化学》2005年第4期454-456,共3页Chinese Journal of Applied Chemistry

摘　　要：Intermediate 6-cyanoindole was obtained from 4-methylbenzonitrile as a raw material via nitration with the mixed acid, condensation with N,N-dimethylformamide dimethyl acetal and cyclic reaction with Raney nickel-hydrazine. 6-Cyanoindole-3-carboxyaldehyde was synthesized via the Vilsmeier reaction of 6-（cyanoindole） with N,N-（diemthylformamide） and phosphorus oxychloride. The structure of the target compound was confirmed by 1H NMR, IR and elemental analysis. The total yield was 57% and the purity of the final （product） reached 99.4%.Intermediate 6-cyanoindole was obtained from 4-methylbenzonitrile as a raw material via nitration with the mixed acid, condensation with N,N-dimethylformamide dimethyl acetal and cyclic reaction with Raney nickel-hydrazine. 6-Cyanoindole-3-carboxyaldehyde was synthesized via the Vilsmeier reaction of 6-(cyanoindole) with N,N-(diemthylformamide) and phosphorus oxychloride. The structure of the target compound was confirmed by ^(1)H NMR, IR and elemental analysis. The total yield was 57% and the purity of the final (product) reached 99.4%.

关 键 词：氰基吲哚 氰基吲哚甲醛 合成 

分 类 号：O625[理学—有机化学]