β-(4-羟基苯基)乳酸的合成  

Synthesis of β-(4-hydroxyphenyl)Lactic Acid

作　　者：邓喜玲[1] 王新兵[1] 相颖[1] 祝世发[1] 

机构地区：[1]石河子大学药学院,新疆石河子832002

出　　处：《石河子大学学报（自然科学版）》2005年第1期11-13,共3页Journal of Shihezi University(Natural Science)

摘　　要：以对羟基苯甲醛为原料 ,经缩合、开环、水解、还原 4步反应制得 β ( 4 羟基苯基 )乳酸。在合成路线中采用了Clemmensen还原法 ,将α 酮酸成功地还原为α 羟基酸 ,此反应为该合成路线的关键步骤。经本文实验表明 ,该合成路线具有原料易得、操作简便、反应条件温和、无需特殊装置设备、成本较低等优点 ,合成总收率为 3 7.4 %。In this paper β-(4-hydroxyphenyl)Lactic Acid was synthesized from 4-hydroxybenzaldehyde by condensation,ring-opening,hydrolysis and reduction.In this experiment α-keto acid was successively converted to α-hydroxyacid by the application of Clemmensen reduction which was the key step.This synthetic route has the advantages of abundant materials,simple process,mild reaction, without special equipments,much lower costs,etc.The overall yield was 37.4%.

关 键 词：β-(4-羟基苯基)乳酸 丹参素衍生物 Clemmensen还原反应 合成 

分 类 号：R972.4[医药卫生—药品]